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The Resource Therapeutic antibodies : methods and protocols, edited by Antony S. Dimitrov

Therapeutic antibodies : methods and protocols, edited by Antony S. Dimitrov

Therapeutic antibodies : methods and protocols
Therapeutic antibodies
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methods and protocols
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edited by Antony S. Dimitrov
With revenues from the top five therapeutic antibodies accounting for a majority of the recent pharmaceutical sales, the research and development in the field has exploded over the past several years and is expected to grow with new emerging monoclonal antibodies like Numax, Lucentis, Actemra, and others. In Therapeutic Antibodies: Methods and Protocols, leading experts from academic laboratories and biotechnology companies present an extensive set of protocols for the discovery and development of therapeutic antibodies, featuring sections devoted to recombinant antigens, antibody libraries, antibody discovery, antibody engineering, and antibody preclinical development. Written in the highly successful Methods in Molecular Biology series format, the chapters contain brief introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes highlighting tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Therapeutic Antibodies: Methods and Protocols serves as a key resource for researchers and antibody engineers investigating and participating in this rapidly growing therapeutic market segment
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non fiction
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  • dictionaries
  • bibliography
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  • Methods in molecular biology,
  • Springer protocols
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Therapeutic antibodies : methods and protocols, edited by Antony S. Dimitrov
Therapeutic antibodies : methods and protocols, edited by Antony S. Dimitrov
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Includes bibliographical references and index
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online resource
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  • Therapeutic antibodies: current state and future trends -- is a paradigm change coming soon? / D.S. Dimitrov and J.D. Marks -- Preparation of recombinant viral glycoproteins for novel and therapeutic antibody discovery / Y.P. Chan [and others] -- Design of a human synthetic combinatorial library of single-chain antibodies / L. Nahary and I. Benhar -- Construction of a human antibody domain (V(H)) library / W. Chen [and others] -- Generation and selection of rabbit antibody libraries by phage display / C. Rader -- Construction of a large naive human phage-displayed Fab library through one-step cloning / Z. Zhu and D.S. Dimitrov -- Identification of target and function specific antibodies for effective drug delivery / Y. Zhou and J.D. Marks -- Screening of specific internalization Fab fragment from human naive phage library by combinational bio-panning / X. Wang and B.B. Cao -- Competitive antigen panning for selection of HIV-1 neutralizing human monoclonal antibodies specific for gp41 / M.Y. Zhang and D.S. Dimitrov -- Selection of non-aggregating V(H) binders from synthetic V(H) phage-display libraries / M. Arbabi-Ghahroudi, R. Mackenzie and J. Tanha -- Isolation of full-length IgG antibodies from combinatorial libraries expressed in Escherichia coli / Y. Mazor [and others] -- Multiplexed flow cytometry: high-throughput screening of single-chain antibodies / J. Ayriss [and others]
  • Human antibody repertoires / P.J. Meijer [and others] -- Rapid screening platform for stabilization of scFvs in Escherichia coli / B.R. Miller, S.M. Glaser and S.J. Demarest -- In vitro antibody affinity maturation targeting germline hotspots / M. Ho and I. Pastan -- Affinity maturation by phage display / H. Thie [and others] -- Production of chimeric heavy-chain antibodies / J. Zhang, R. Mackenzie and Y. Durocher -- Mammalian cell display for antibody engineering / M. Ho and I. Pastan -- Improving antibody binding affinity and specificity for therapeutic development / J. Bostrom [and others] -- Construction and production of an IgG-like tetravalent bispecific antibody for enhanced therapeutic efficacy / D. Lu and Z. Zhu -- Deimmunization of monoclonal antibodies / T.D. Jones [and others] -- Anti-CD22 onconase: preparation and characterization / D.L. Newton, L.H. Stockwin and S.M. Rybak -- Antibody-cytotoxic agent conjugates: preparation and characterization / R. Singh and H.K. Erickson -- High-level production of a humanized immunoRNase fusion protein from stably transfected myeloma cells / J. Krauss [and others] -- Antibody fragment expression and purification / D. Dimitrova, V. Choudhry and C.C. Broder -- Scaling-up and production of therapeutic antibodies for preclinical studies / Y. Feng and D.S. Dimitrov -- Antibody production by the gram-positive bacterium Bacillus megaterium / E. Jordan [and others] -- Neutralization of HIV by antibodies / I. Prado, T.R. Fouts and A.S. Dimitrov -- Dynamics of antibody domains studied by solution NMR / B.K. Vu [and others] -- In vivo method for establishing synergy between antibodies to epidermal growth factor receptor and vascular endothelial growth factor receptor-2 / J.R. Tonra [and others] -- Passive immunization with human neutralizing monoclonal antibodies against HIV-1 in macaque models: experimental approaches / R.M. Ruprecht -- Organizing, exploring, and analyzing antibody sequence data: the case for relational-database managers / J. Owens
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1 online resource (xviii, 585 pages, [8] pages of plates)
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illustrations (some color).
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      110 8th St, Troy, NY, 12180, US
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