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The Resource The Structural Basis of Arrestin Functions, edited by Vsevolod V. Gurevich, (electronic resource)

The Structural Basis of Arrestin Functions, edited by Vsevolod V. Gurevich, (electronic resource)

Label
The Structural Basis of Arrestin Functions
Title
The Structural Basis of Arrestin Functions
Statement of responsibility
edited by Vsevolod V. Gurevich
Contributor
Editor
Subject
Language
eng
Summary
This volume summarizes our current understanding of the structural basis of the functions of arrestin family of proteins. Arrestins were first discovered as key players in the desensitization of G protein-coupled receptors (GPCRs). Recent studies showed that arrestins are important signal transducers in their own right, organizing multi-protein complexes and scaffolding numerous signaling cascades that regulate cell proliferation, differentiation, and apoptotic death. Here arrestin functions are described primarily from the structural prospective. The book covers basal structure of arrestin proteins, receptor binding-induced conformational changes in arrestins, as well as the structure of 2pre-activated3 mutants. Particular focus is on the arrestin elements interacting with numerous binding partners, GPCRs and cytoplasmic signaling proteins. We expect that this information and insights will help to understand and exploit the phenomenon of signaling bias, which is a new promising direction in drug discovery. The chapters are written by the world-class specialists in the field, mostly the people who actually contributed the data discussed. The book gives coherent historical prospective and describes the most recent findings. The book would be particularly useful for scientists in academia and industry working in the fields of pharmacology, cell biology, structural biology, and drug discovery. We expect that the focus on the molecular basis of protein-protein interactions would help to develop novel tools for engaging this important type of targets for research and therapeutic purposes
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non fiction
The Structural Basis of Arrestin Functions, edited by Vsevolod V. Gurevich, (electronic resource)
Label
The Structural Basis of Arrestin Functions, edited by Vsevolod V. Gurevich, (electronic resource)
Link
http://libproxy.rpi.edu/login?url=http://dx.doi.org/10.1007/978-3-319-57553-7
Publication
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Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Arrestins: discovery of the family and functional role of conformational flexibility -- Overview of arrestin-mediated signaling with receptors and non-receptor binding partners -- Initial crystallographic studies of visual arrestin: insights and perspectives -- Structural basis for b-arrestins in GPCR trafficking -- Arrestin-3: the structural basis of lower receptor selectivity -- Phosphate sensor and construction of phosphorylation-independent arrestins -- Comprehensive analysis of the role of arrestin residues in receptor binding -- How arrestin recognizes and binds active GPCRs -- Localization of conformational dynamics of arrestins by HDX-MS -- GPCR footprint on arrestins and manipulation of receptor specificity -- The structure of the polar core mutant R175E and its functional implications -- Active conformations of arrestins: expected and unexpected changes -- The arrestin-receptor complex: exciting answers and new questions -- Scaffolding c-Jun N-terminal kinase cascades: mechanistic insights from the reconstituted arrestin-JNK cascades -- Arrestin-dependent ERK activation and its disruption -- The functional role of the conformational changes in arrestin upon activation -- Is signaling specificity encoded in arrestin conformation? -- Monofunctional elements of multi-functional arrestin proteins -- Arrestins in cell death
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https://contentcafe2.btol.com/ContentCafe/Jacket.aspx?Return=1&Type=S&Value=9783319575537&userID=ebsco-test&password=ebsco-test
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unknown
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{'f': 'http://opac.lib.rpi.edu/record=b4258214'}
Extent
IX, 304 p. 53 illus., 51 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319575537
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote

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