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The Resource Telomeres and telomerase : methods and protocols, edited by John A. Double and Michael J. Thompson

Telomeres and telomerase : methods and protocols, edited by John A. Double and Michael J. Thompson

Label
Telomeres and telomerase : methods and protocols
Title
Telomeres and telomerase
Title remainder
methods and protocols
Statement of responsibility
edited by John A. Double and Michael J. Thompson
Contributor
Subject
Genre
Language
eng
Summary
The discovery of telomerase expression in a majority of tumors and the recognition of its potential role in the aging process has dramatically raised its profile as a target for therapeutic intervention. In Telomeres and Telomerase: Methods and Protocols, John A. Double and Michael J. Thompson have collected a critically important series of novel and essential techniques for studying telomeres and telomerase. These readily reproducible protocols provide cutting-edge tools to identify, measure, and analyze telomeres, to determine telomerase expression at the RNA level, to determine telomerase activity, and to detect potential modifiers of this activity. The techniques for assaying telomerase activity range from standard radiological TRAP assays to nonradioactive methods, from non-PCR-based methods to techniques using real-time PCR. Written by investigators who have used the methods extensively, each protocol includes step-by-step instructions, tips on avoiding pitfalls, and invaluable notes that make all the difference to successful experimental outcomes. Broad-ranging and highly practical, Telomeres and Telomerase: Methods and Protocols provides molecular and cell biologists, cancer researchers, and cellular pathologists with the core array of productive techniques needed today to develop telomerase inhibitors and clinically valuable diagnostic/prognostic telomerase markers
Member of
Cataloging source
N$T
Illustrations
illustrations
Index
index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
Series statement
Methods in molecular biology
Series volume
v. 191
Telomeres and telomerase : methods and protocols, edited by John A. Double and Michael J. Thompson
Label
Telomeres and telomerase : methods and protocols, edited by John A. Double and Michael J. Thompson
Link
http://libproxy.rpi.edu/login?url=http://link.springer.com/10.1385/1592591892
Publication
Related Contributor
Related Location
Related Agents
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Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Introduction to telomeres and telomerase / Michael C. Bibby -- Detection of chromosome ends by telomere FISH / Harry Scherthan -- Telomere length distriubtion : digital image processing and statistical analysis / Jean-Patrick Pommier and Laure Sabatier -- Analysis of telomerase RNA gene expression by In Situ hybridization / W. Nicol Keith, Joseph Sarvesvaran and Martin Downey -- Relative gene expression in normal and tumor tissue by quantitative RT-PCR / Dennis S. Salonga, Kathleen D. Danenberg, Jean Grem, Ji Min Park and Peter V. Danenberg -- Quantitative detection of telomerase components by real-time, online RT-PCR analysis with the LightCycler / Thomas Emrich, Sheng-Yung Chang, Gerlinde Karl, Birgit Panzinger, and Chris Santini -- Standard TRAP assay / Angelika M. Burger -- Stretch PCR assay / Jun-ichi Nakayama and Fuyuki Ishikawa -- Fluorescent detection of telomerase activity / Wade K. Aldous, Amber J. Marean, Mary J. DeHart and Katherine H. Moore -- Nonradioactive detection of telomerase activity using a PCR-ELISA-based telomeric repeat amplification protocol / Thomas Emirch and Gerlinde Karl -- In Sute TRAP assay detection of telomerase activity in cytological preparations / Kazuma Ohyashiki and Junko H. Ohyashiki -- Biotinylated primer for detecting telomerase activity without amplification / Daekyu Sun -- Whole-cell and microcell fusion for the identification of natural regulators of telomerase / Henriette Gourdeau, Marsha D. Speevak, Lucie Jetté and Mario Chevrette -- Screening with COMPARE analysis for telomerase inhibitors / Imad Naasani, Takao Yamori and Takashi Tsuruo -- Telomerase as a therapeutic target : therapeutic potential of telomerase inhibitors / John A. Double
http://library.link/vocab/cover_art
https://contentcafe2.btol.com/ContentCafe/Jacket.aspx?Return=1&Type=S&Value=9780896036574&userID=ebsco-test&password=ebsco-test
Dimensions
unknown
http://library.link/vocab/discovery_link
{'f': 'http://opac.lib.rpi.edu/record=b3356718'}
Extent
1 online resource (xi, 221 pages)
Form of item
online
Isbn
9780896036574
Lccn
2001039598
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations.
Specific material designation
remote

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