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The Resource Sigma Proteins: Evolution of the Concept of Sigma Receptors, edited by Felix J. Kim, Gavril W. Pasternak, (electronic resource)

Sigma Proteins: Evolution of the Concept of Sigma Receptors, edited by Felix J. Kim, Gavril W. Pasternak, (electronic resource)

Label
Sigma Proteins: Evolution of the Concept of Sigma Receptors
Title
Sigma Proteins: Evolution of the Concept of Sigma Receptors
Statement of responsibility
edited by Felix J. Kim, Gavril W. Pasternak
Contributor
Editor
Subject
Language
eng
Summary
Two sigma receptor subtypes have been proposed, sigma1 and 2. Much of our understanding of this system is based on biochemical and pharmacological characterization of the cloned sigma1 receptor subtype (Sigma1). It has become clear that sigma receptors are not canonical receptors. Sigma1 is highly conserved among mammalian species, however, it does not share significant homology with any other mammalian protein. Although a range of structurally diverse small molecules bind Sigma1 with high affinity, and it has been associated with a broad range of signaling systems, Sigma1 itself has no known signaling or enzymatic activity. The evolution of this field over nearly four decades has more recently led to a fundamental shift in the concept of 2sigma receptors3 to what may more accurately and generally be called sigma proteins. Largely based on traditional pharmacologic approaches, the Sigma1 protein has been associated with a broad range of signaling systems, including G-protein coupled receptors, NMDA receptors, and ion channels. Sigma proteins have been linked to a range of physiological processes, including intracellular calcium signaling, neuroprotection, learning, memory, and cognition. Emerging genetic, clinical, and mechanism focused molecular pharmacology data demonstrate the involvement of proteins in a range of pathophysiologies and disorders including neurodegenerative disease, pain, addiction, psychomotor stimulant abuse, and cancer. However, an understanding of the physiological role of sigma proteins has remained elusive. Emerging data associate Sigma1 with chaperone-like activities or molecular scaffold functions. This book aims to provide an updated perspective on this rapidly evolving field undergoing changes in fundamental concepts of key importance to the discipline of pharmacology. It focusses on the reported roles of sigma proteins in pathophysiology and on emergent therapeutic initiatives
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Image bit depth
0
Literary form
non fiction
Series statement
Handbook of Experimental Pharmacology,
Series volume
244
Sigma Proteins: Evolution of the Concept of Sigma Receptors, edited by Felix J. Kim, Gavril W. Pasternak, (electronic resource)
Label
Sigma Proteins: Evolution of the Concept of Sigma Receptors, edited by Felix J. Kim, Gavril W. Pasternak, (electronic resource)
Link
http://libproxy.rpi.edu/login?url=http://dx.doi.org/10.1007/978-3-319-65853-7
Publication
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Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Preface -- Historical perspective and background - including Sigma protein subtypes and ligand selectivity -- Sigma imaging agents -- Medicinal chemistry -- 3-dimensional homology models of Sigma1 -- Neuronal plasticity and ion channels -- Opioid receptors and other GPCR -- Cancer -- Neurodegenerative diseases -- Pain -- Cognition, learning, neurological disorders -- Drug abuse and addiction -- Alcohol Abuse -- Stroke and neuroprotection
http://library.link/vocab/cover_art
https://contentcafe2.btol.com/ContentCafe/Jacket.aspx?Return=1&Type=S&Value=9783319658537&userID=ebsco-test&password=ebsco-test
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unknown
http://library.link/vocab/discovery_link
{'f': 'http://opac.lib.rpi.edu/record=b4380126'}
Extent
VIII, 330 p. 64 illus., 32 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319658537
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote

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