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The Resource Recombinant antibodies for cancer therapy : methods and protocols, edited by Martin Welschof and Jürgen Krauss

Recombinant antibodies for cancer therapy : methods and protocols, edited by Martin Welschof and Jürgen Krauss

Label
Recombinant antibodies for cancer therapy : methods and protocols
Title
Recombinant antibodies for cancer therapy
Title remainder
methods and protocols
Statement of responsibility
edited by Martin Welschof and Jürgen Krauss
Contributor
Subject
Genre
Language
eng
Summary
Many antibodies recently developed as therapeutic agents have been tailored by the powerful new recombinant antibody technology, and already their clinical data show highly encouraging results. In Recombinant Antibodies for Cancer Therapy: Methods and Protocols, Martin Welschof and Jürgen Krauss present a collection of carefully selected protocols for the design, construction, and characterization of those novel anticancer therapeutics. Written by seasoned investigators who have successfully verified the particular method described, these readily reproducible methods include coverage of hybridoma-derived recombinant antibodies, recombinant antibody fragments from phagemid-displayed antibody repertoires, antibody fragments with additional properties, and large-scale production of recombinant antibodies for clinical applications. The main focus is on providing detailed protocols that describe these procedures step-by-step, accompanied by a troubleshooting guide discussing possible problems and offering many tips for their potential solutions. Concise review articles also survey the current status of recombinant antibodies in cancer therapy, as well as the generation of antibody molecules through antibody engineering. Up-to-date and highly practical, Recombinant Antibodies for Cancer Therapy: Methods and Protocols surveys the current status of engineered antibodies and describes in rich detail many readily reproducible methods of generating the novel and promising antibody-based reagents of today's cancer therapy
Member of
Cataloging source
COO
Illustrations
illustrations
Index
index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
Series statement
Methods in molecular biology
Series volume
v. 207
Recombinant antibodies for cancer therapy : methods and protocols, edited by Martin Welschof and Jürgen Krauss
Label
Recombinant antibodies for cancer therapy : methods and protocols, edited by Martin Welschof and Jürgen Krauss
Link
http://libproxy.rpi.edu/login?url=http://link.springer.com/10.1385/1592593348
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Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Generation of antibody molecules through antibody engineering / S.M. Kipriyanov -- Application of recombinant antibodies in cancer patients / J. Krauss, M. Arndt and M. Pfreundschuh -- DNA immunization as a means to generate antibodies to proteins / P.S. Chowdhury -- Chimerization of a monoclonal antibody for treating hodgkin's lymphoma / J. Krauss [and others] -- Humanization of monoclonal antibodies by CDR grafting / S. O'Brien and T. Jones -- Generation and screening of a modular human scFv expression library from multiple donors / M. Welschof [and others] -- Construction of semisynthetic antibody libraries / M. Braunagel -- Single-domain VH antibody fragments from a phage display library / L. Binyamin, D. Plaksin and Y. Reiter -- Isolation of human fab fragments against ovarian carcinoma using guided selection / M. Figini [and others] -- Human recombinant fab antibodies with t-cell receptor-like specificities generated from phage display libraries / J. Engberg [and others] -- Engineering hot spots for affinity enhancement of antibodies / P.S. Chowdhury -- Simultaneous humanization and affinity optimization of monoclonal antibodies / H. Wu -- Tailoring kinetics of antibodies using focused combinatorial libraries / H. Wu and L.L. An -- Engineering scFvs for improved stability / P.S. Chowdhury and G. Vasmatzis -- Recombinant single-chain and disulfide-stabilized Fv immunotoxins for cancer therapy / R. Niv, D. Segal and Y. Reiter -- Generation of recombinant immunotoxins for specific targeting of tumor-related peptides presented by MHC molecules / C.J. Cohen [and others] -- Construction and characterization of RNase-based targeted therapeutics / D.L. Newton [and others] -- Bispecific diabodies for cancer therapy / M. Arndt and J. Krauss -- Generation and characterization of bispecific tandem diabodies for tumor therapy / S.M. Kipriyanov -- Generation of recombinant multimeric antibody fragments for tumor diagnosis and therapy / B.E. Power, A.A. Kortt and P.J. Hudson -- Construction and characterization of minibodies for imaging and therapy of colorectal carcinomas / P.J. Yazaki and A.M. Wu -- Generation, expression, and monitoring of recombinant immune receptors for use in cellular immunotherapy / A. Hombach, C. Heuser and H. Abken -- Tailoring natural effector functions. Antibody engineering beyond humanization / O.H. Brekke and J.E. Thommesen -- Single-chain Fv-based affinity purification of the cellular stress protein GP96 for vaccine development / C. Kleist [and others] -- Recombinant adenoviruses for in vivo expression of antibody fragments / R.E. Kontermann, T. Korn and V. Jerome -- Production of antibody fragments in a bioreactor / H. Hellebust -- Large scale production of recombinant antibodies by utilizing cellulose-binding domains / I. Benhar and Y. Berdichevsky -- Production of tumor-specific antibodies in tobacco / C. Vaquero-Martin and R. Fischer
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Dimensions
unknown
http://library.link/vocab/discovery_link
{'f': 'http://opac.lib.rpi.edu/record=b3356950'}
Extent
1 online resource (xiv, 481 pages)
Form of item
online
Isbn
9780896039186
Lccn
2002067889
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations.
Specific material designation
remote

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