Coverart for item
The Resource Proteases and cancer : methods and protocols, edited by Toni M. Antalis and Thomas H. Bugge

Proteases and cancer : methods and protocols, edited by Toni M. Antalis and Thomas H. Bugge

Label
Proteases and cancer : methods and protocols
Title
Proteases and cancer
Title remainder
methods and protocols
Statement of responsibility
edited by Toni M. Antalis and Thomas H. Bugge
Contributor
Subject
Genre
Language
eng
Summary
Proteases decisively contribute to cancer development and promotion by regulating the activities of growth factors/cytokines and signaling receptors, as well as the composition of the extracellular matrix, thereby suppressing cell death pathways and activating cell survival pathways. In Proteases and Cancer: Methods and Protocols, expert researchers bring together a wide range of current, complimentary techniques that have been developed for the specific detection and analysis of proteases and their activities in cancer biology. The volume covers vital topics including the application of proteomics technologies for the detection of protease expression in tumors, imaging proteases by activity profiling, proteomics technologies for the identification of biological substrates, detection of cell surface proteolysis, imaging of protease activity, the use of transgenic mice to determine protease function in tumor initiation and progression, and the development of anti-protease therapies for cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Proteases and Cancer: Methods and Protocols is an ideal guide for scientists who wish to pursue the study of this important branch of cancer research and the development of unique innovative technologies to aid in that study
Member of
Cataloging source
CUS
Illustrations
  • illustrations
  • plates
Index
index present
Language note
English
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
Series statement
  • Methods in molecular biology,
  • Springer protocols
Series volume
539
Proteases and cancer : methods and protocols, edited by Toni M. Antalis and Thomas H. Bugge
Label
Proteases and cancer : methods and protocols, edited by Toni M. Antalis and Thomas H. Bugge
Link
http://libproxy.rpi.edu/login?url=http://link.springer.com/10.1007/978-1-60327-003-8
Publication
Related Contributor
Related Location
Related Agents
Related Authorities
Related Subjects
Related Items
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Delineating protease functions during cancer development / Nesrine I. Affara, Pauline Andreu, and Lisa M. Coussens -- Proteolytic systems : constructing degradomes / Gonzalo R. Ordóñez [and others] -- Microarrays for protease detection in tissues and cells / Kamiar Moin [and others] -- Positional scanning synthetic combinatorial libraries for substrate profiling / Eric L. Schneider and Charles S. Craik -- Mixture-based peptide libraries for identifying protease cleavage motifs / Benjamin E. Turk -- High throughput substrate phage display for protease profiling / Boris Ratnikov, Piotr Cieplak, and Jeffrey W. Smith -- Imaging specific cell surface protease activity in living cells using reengineered bacterial cytotoxins / John P. Hobson [and others] -- Cell-based identification of natural substrates and cleavage sites for extracellular proteases by SILAC proteomics / Magda Gioia, Leonard J. Foster, and Christopher M. Overall -- Optical proteolytic beacons for in vivo detection of matrix metalloproteinase activity / J. Oliver McIntyre and Lynn M. Matrisian -- Dissecting the urokinase activation pathway using urokinase-activated anthrax toxin / Shihui Liu [and others] -- On-demand cleavable linkers for radioimmunotherapy / Pappanaicken R. Kumaresan, Juntao Luo and Kit S. Lam
http://library.link/vocab/cover_art
https://contentcafe2.btol.com/ContentCafe/Jacket.aspx?Return=1&Type=S&Value=9781603270038&userID=ebsco-test&password=ebsco-test
Dimensions
unknown
http://library.link/vocab/discovery_link
{'f': 'http://opac.lib.rpi.edu/record=b3357361'}
Extent
1 online resource (xii, 221 pages, [2] pages of plates)
Form of item
online
Isbn
9781603270038
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations (some color).
Sound
unknown sound
Specific material designation
remote

Library Locations

    • Folsom LibraryBorrow it
      110 8th St, Troy, NY, 12180, US
      42.729766 -73.682577
Processing Feedback ...