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The Resource Primary Sclerosing Cholangitis : Current Understanding, Management, and Future Developments

Primary Sclerosing Cholangitis : Current Understanding, Management, and Future Developments

Label
Primary Sclerosing Cholangitis : Current Understanding, Management, and Future Developments
Title
Primary Sclerosing Cholangitis
Title remainder
Current Understanding, Management, and Future Developments
Creator
Subject
Language
eng
Cataloging source
MiAaPQ
Literary form
non fiction
Nature of contents
dictionaries
Primary Sclerosing Cholangitis : Current Understanding, Management, and Future Developments
Label
Primary Sclerosing Cholangitis : Current Understanding, Management, and Future Developments
Link
http://libproxy.rpi.edu/login?url=https://ebookcentral.proquest.com/lib/rpi/detail.action?docID=4742088
Publication
Copyright
Related Contributor
Related Location
Related Agents
Related Authorities
Related Subjects
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • Preface -- Acknowledgments -- Contents -- Contributors -- 1: Epidemiology and Natural History of Primary Sclerosing Cholangitis -- Introduction -- Diagnosis -- Signs and Symptoms -- Diagnostic Evaluation -- Epidemiology -- Prevalence and Incidence Rates -- Demographics -- Natural History -- Risk Prediction in PSC -- Clinical Phenotypes -- Complications -- Malignancy in PSC -- Nonmalignant Outcomes of PSC -- Dominant Stricture -- Bacterial Cholangitis -- Hepatic Osteodystrophy -- References -- 2: Malignancy and Primary Sclerosing Cholangitis: Cholangiocarcinoma, Hepatocellular Carcinoma, and Gallbladder Carcinoma -- Cholangiocarcinoma -- Introduction -- Epidemiology -- Pathogenesis -- Risk Factors -- Screening -- Diagnosis -- Overview -- Imaging -- CA 19-9 -- Biliary Brushing -- Fluorescence In Situ Hybridization -- Cholangioscopy with Biopsy -- Endoscopic Ultrasound -- Management -- Surgical Resection -- Liver Transplantation -- Palliative Therapies -- Hepatocellular Carcinoma -- Introduction -- Epidemiology -- Pathogenesis -- Risk Factors -- Screening -- Diagnosis -- Imaging -- Biopsy -- Staging -- Management -- Surgical Resection -- Liver Transplantation and the Milan Criteria -- Expanded Criteria -- Living Donor Transplantation -- Non-curative Treatment -- Locoregional Therapy -- Systemic Chemotherapy -- Gallbladder Carcinoma -- Introduction -- Epidemiology -- Risk Factors -- Pathogenesis -- Screening -- Diagnosis -- Treatment -- Surgical Management -- Advanced Stage -- Prognosis -- References -- 3: Primary Sclerosing Cholangitis-Associated Inflammatory Bowel Disease -- Epidemiology of PSC-Associated IBD (PSC-IBD) -- Pathophysiology of PSC-IBD -- IBD Phenotype in PSC-IBD Patients -- Colorectal Cancer Risk, Prevention, and Management in PSC-IBD Patients -- Colectomy and Pouch Function in PSC-IBD Patients
  • Effect of IBD on Transplant Outcomes Among PSC-IBD Patients -- Effect of Liver Transplantation on IBD Activity Among PSC-IBD Patients -- Management of PSC-IBD Following Liver Transplantation -- Summary -- References -- 4: Overlap Syndromes of Primary Sclerosing Cholangitis -- Diagnostic Criteria -- Diagnostic Scoring System -- Diagnostic Requisites -- Key Cholestatic Indices -- Histological Examination -- Salient Clinical Features of the Overlap Syndrome of PSC and AIH -- Salient Clinical Features of the Overlap Syndrome of PSC and PBC -- Frequency -- Autoimmune Cholangitis -- Pathogenic Considerations -- Treatment Regimens -- Outcomes -- Overview -- References -- 5: IgG4-Related Sclerosing Cholangitis -- Introduction -- The Discovery of IgG4-Related Sclerosing Cholangitis -- Epidemiology -- Disease Pathogenesis -- Genetic Susceptibility -- Autoantigens -- The Role of B Cells and the IgG4 Molecule -- T-Cell Immunological Response -- Regional Factors Promoting Lymphocyte Recruitment -- Clinical Features and Natural History -- Clinical Presentation -- Laboratory Findings -- Imaging Features -- Histopathological Features -- Diagnosis -- Treatment -- Prognosis -- Summary -- References -- 6: Pediatric Primary Sclerosing Cholangitis -- Introduction -- Epidemiology -- Diagnosis of PSC -- Natural History and Outcomes in Pediatric PSC -- Subtypes of Pediatric PSC -- Autoimmune Sclerosing Cholangitis (PSC-AIH Overlap Syndrome) -- Small Duct PSC -- PSC and Inflammatory Bowel Disease -- Secondary Sclerosing Cholangitis -- Therapies for PSC -- Summary -- References -- 7: Cholangiocyte Biology -- Introduction -- Cholangiocyte Biology -- Structural Features -- Functional Features -- Cholangiocyte Plasticity -- Summary -- References -- 8: Genetics of Primary Sclerosing Cholangitis -- Introduction -- GWAS and Liver Disease Genetics -- The HLA Association in PSC
  • Non-HLA Associations in PSC -- Practical Implications of Novel Gene Associations -- References -- 9: Immunology of Primary Sclerosing Cholangitis -- Introduction -- Biliary Anatomic Features and PSC -- Pathology of PSC -- Innate and Adaptive Immunity -- Innate Immunity -- Innate Immunity in PSC -- Adaptive Immunity -- HLA -- Effector T Cells and Cytokines -- Adaptive Immunity in PSC -- Transendothelial Leukocyte Trafficking into Tissues -- Progress Toward an Understanding of Immunopathogenesis -- Genetics -- Genome-Wide Association Studies (GWAS) -- Fucosyltransferase 2 (FUT2) -- HLA and Susceptibility to PSC -- Non-MHC Genes and Susceptibility to PSC -- MHC Genes and Resistance to PSC -- Non-MHC Genes and Resistance to PSC -- Immunogenetics of Disease Progression and Complications of PSC -- Autoantibodies in PSC -- Nuclear Envelope Autoantigens and Bacterial Mimicry -- Cholangiocyte-Specific Autoantigens and CD44 -- Nonspecific Autoantibodies -- Immunological Epiphenomena -- Cholangiocytes in the Immuno{u00AD}pathogenesis of PSC -- Cholangiocytes as Immunological Targets in PSC -- Immunomodulatory Roles of Cholangiocytes -- Endothelial Cells and the Role of Arterial Ischemia in PSC -- Emerging Role of Gut Microbiota -- Immunopathogenic Role of Gut-{u00AD}Primed T Cells, Aberrant Expression of Adhesion Molecules, Chemokines, and Cytokines -- Key Unanswered Questions About PSC Immunopathogenesis -- Bile Regurgitation into the Peribiliary Space and Consequences of Biliary Obstruction -- Contribution of Biliary Obstruction to Pathogenesis -- References -- 10: Pruritus in Primary Sclerosing Cholangitis: New Insights into Cause and Treatment -- Introduction -- The Pathophysiology of Itch -- Summary -- What Causes PSC Patients to Itch? -- Rational Approach to Treating Pruritus in PSC Patients -- Closing Remarks -- References
  • 11: Ursodeoxycholic Acid Treatment in Primary Sclerosing Cholangitis -- Overview and Clinical Epidemiology -- Proposed Etiopathogenesis of and the Basis of Bile Acid Therapy in PSC -- Clinical Trials of UDCA in PSC -- Potential Chemopreventive Properties of UDCA Against Colorectal Cancer -- UDCA in Clinical Practice -- UDCA in PSC: Conclusions -- References -- 12: Future Therapies for Primary Sclerosing Cholangitis -- Introduction -- Pathogenesis and Opportunities for Therapeutic Targets -- Gut-Liver Axis in PSC and IBD -- Therapeutic Targeting of the Gut-{u00AD}Liver Axis -- Gut Microbiome -- Gut Adhesion Molecules and Enterohepatic Circulation -- Bicarbonate Umbrella and Toxic Bile Acids in PSC -- Therapeutic Targeting of Toxic Bile -- UDCA Derivative -- Suppression of Bile Acid Biosynthesis -- Depletion of Bile Acid Pool -- Etiology-Independent Therapeutic Agents -- Therapeutic Agents Against Fibrogenesis -- Therapeutic Agents Against Inflammation and Cell Injury -- Safety and Tolerability of Novel Therapeutic Agents -- Limitations of Current Approaches to the Development of Future Therapies for PSC -- References -- 13: Noninvasive Imaging of Primary Sclerosing Cholangitis: A Radiologic Perspective -- Introduction -- Radiologic-Pathologic Correlation -- Transabdominal Ultrasound (US) -- Computed Tomography (CT) -- Magnetic Resonance Imaging (MRI) -- Magnetic Resonance Cholangiography (MRC) -- MR Elastography (MRE) -- Positron Emission Tomography/Computed Tomography (PET/CT) -- Presurgical Staging of Cholangiocarcinoma -- References -- 14: Endoscopic Evaluation and Management of Primary Sclerosing Cholangitis -- Introduction -- Endoscopic Evaluation of PSC -- Endoscopic Therapy for PSC -- Endoscopic Sphincterotomy -- Balloon Dilation vs. Stenting of Dominant Stenoses -- Endoscopic Evaluation for Malignancy in PSC -- Diagnostic Workup
  • Endoscopic Evaluation of Dominant Biliary Strictures in PSC -- Brush Cytology -- Endoscopic Ultrasound -- Fluorescence In Situ Hybridization (FISH) -- Intraductal Endoscopy -- Probe-Based Confocal Laser Endomicroscopy (pCLE) -- Antibiotic Prophylaxis -- Adverse Events of ERCP in PSC -- Role of Endoscopy in Recurrent PSC After Liver Transplantation -- Conclusions and Future Directions -- References -- 15: Percutaneous Biliary Intervention in Patients with Primary Sclerosing Cholangitis -- Indications for Percutaneous Intervention -- Diagnosis of PSC -- Treatment of Cholangitis Refractory to Medical or Endoscopic Therapy -- Diagnosis and Palliation of Biliary Obstruction in Patients with CCA -- Procedural Description -- Percutaneous Transhepatic Cholangiography -- Percutaneous Transhepatic Drainage and Stricture Dilation -- Results -- Percutaneous Transhepatic Cholangiography for PSC Diagnosis -- Percutaneous Transhepatic Drainage and Stricture Dilation -- Complications and Management -- References -- 16: Liver Transplantation for PSC -- Indications -- Recipient Evaluation -- Graft Allocation -- Donor Selection -- The Operation -- Posttransplant Outcomes -- Posttransplant Quality of Life -- References -- 17: Recurrent Primary Sclerosing Cholangitis After Liver Transplantation -- Recurrent Disease After Transplant -- Diagnosis of Recurrent PSC -- Treatment of Recurrent PSC -- Natural History of PSC After Liver Transplant -- Living Donor Liver Transplantation -- Summary Paragraph -- References -- Index
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{'f': 'http://opac.lib.rpi.edu/record=b4386547'}
Extent
1 online resource (226 pages)
Form of item
online
Isbn
9783319409085
Media category
computer
Media MARC source
rdamedia
Media type code
c
Sound
unknown sound
Specific material designation
remote

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