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The Resource Preserving the Promise : Improving the Culture of Biotech Investment

Preserving the Promise : Improving the Culture of Biotech Investment

Preserving the Promise : Improving the Culture of Biotech Investment
Preserving the Promise
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Improving the Culture of Biotech Investment
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Preserving the Promise : Improving the Culture of Biotech Investment
Preserving the Promise : Improving the Culture of Biotech Investment
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  • Front Cover -- Preserving the Promise -- Copyright Page -- Contents -- Preface -- Acknowledgments -- Innovation Meets the Translation Gap -- 1 Stop the Madness and Cure Something -- 2 Into the Valley of Death -- References -- 3 Clinical Promise {u2260} Investment Practice -- References -- 4 Velcade, a Biotech Success Story -- References -- 5 Biotechnology and the Future of Pharma -- References -- 6 Why Pharma Should Care About the Valley of Death -- References -- 7 Porter's Five Forces and the Market for Angel Capital -- A Paradigm for Analysis -- The Prospect of Total Loss -- References -- 8 Out of the Frying Pan: The Fire's Not So Great Either -- Juggling Interest, Support, Commitment, and IP -- A Fulcrum of Tension -- The Special Case of Conflict of Interest -- References -- 9 Getting to Australia -- Reaching the Limits -- References -- Translation Gap 1: Universities Don't Make What Companies Need -- 10 When Is an Experiment Ready for the Valley of Death? -- Why Not Simply License the Technology to a Big Healthcare Company? -- Collaboration and Conflict -- References -- 11 Unintended Consequences of Applying for a Patent -- The Dollars Begin to Flow -- The Real Costs of a Patent Application -- References -- 12 What if It Doesn't Actually Work? -- References -- 13 Building a Better Mousetrap -- References -- Translation Gap 2: Good Innovation Is Not Always a Good Investment -- 14 Due Diligence and Angel Incentives -- How Angels Decide -- Due Diligence-An Overview -- Due Diligence-Getting Specific -- Exogenous Factors -- Unmet Clinical or Professional Need -- Size and Growth of the Addressable Market -- Adaptability of the Technology or Product to Clinical Practice -- Potential for Sustainable Competitive Advantage -- References -- 15 What Is Value? -- Attractiveness and Plausibility of the Technology
  • Likelihood that Clinical Proof of Concept is Achievable -- Challenges of the Regulatory Environment -- Attractiveness of the Business Model -- Financial Viability -- Exit Strategy -- Human Resources and Contingency Planning -- Reflections on Due Diligence -- So Where is Big Pharma/Big Biotech on All This? A Breakdown in Value -- References -- 16 Angels at the Crux of Invention -- Bad Stuff Gets Funded and Good Stuff Dies -- The Uncertainty of Scientific Due Diligence -- Investing to the Next Money -- References -- 17 Investment: A Nuanced Decision -- References -- 18 Ready for a Long-Term Relationship With a Science Experiment? -- Due Diligence Versus De-Risking -- Financing the Biotechnology Start-up -- Buying and Selling in the VoD -- The Perils of Convertible Debt -- References -- 19 Investing in Hockey Sticks -- The Hockey Stick-A Matter of Inflection -- Milestone Driven Investments -- The Perfect Deal -- ROI Versus Innovation -- References -- 20 Harps for Angels -- Consideration of the Macro Environment -- Regional, Economic, and Cultural Influences -- References -- 21 Connecting Innovation to Investment -- Reducing the Risk of Scientific Failure -- Rewarding the Long Game -- References -- Translation Gap 3: Technology Transfer Wastes Money and Innovation -- 22 Mitigating Supplier Power -- How It's Not Supposed to Work -- The Real Costs of Supplier Power -- Reducing the Costs of Technology Transfer -- Assignment of an Invention: What If We Give It Away? -- An Ounce of Prevention -- References -- 23 Preventing Speeding by Closing the Road -- Aligning Incentives -- References -- 24 Breaking Old Habits -- Company Building as a Focus of Technology Transfer -- Building an Innovation Community -- What is the Least We Can Do? -- The Minimal Commercialization Unit -- References -- Epilogue -- 25 Epilogue: Why We Do This -- References -- Index
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1 online resource (277 pages)
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    • Folsom LibraryBorrow it
      110 8th St, Troy, NY, 12180, US
      42.729766 -73.682577
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