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The Resource Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins, edited by Ulf Grawunder, Stefan Barth, (electronic resource)

Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins, edited by Ulf Grawunder, Stefan Barth, (electronic resource)

Label
Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins
Title
Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins
Statement of responsibility
edited by Ulf Grawunder, Stefan Barth
Contributor
Editor
Subject
Language
eng
Summary
This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities. The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology
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Is part of
Image bit depth
0
Literary form
non fiction
Series statement
Milestones in Drug Therapy,
Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins, edited by Ulf Grawunder, Stefan Barth, (electronic resource)
Label
Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins, edited by Ulf Grawunder, Stefan Barth, (electronic resource)
Link
http://libproxy.rpi.edu/login?url=http://dx.doi.org/10.1007/978-3-319-46877-8
Publication
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Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Chemical Assembly of Antibody-Drug Conjugates -- Pre-clinical evaluation of ADCs delivering highly potent pyrrolobenzodiazepine (PBD) dimers -- Stable and homogeneous drug conjugation by sequential bis-alkylation at disulfide bonds using bis-sulfone reagents -- Calicheamicin antibody-drug conjugates for liquid- and solid tumor indications -- Enzyme-based strategies to generate site-specifically conjugated Antibody Drug Conjugates -- Substance P {u2013} Saporin for the Treatment of Intractable Pain -- Recombinant immunotoxins for Chronic Inflammatory Disease -- BL22: A milestone in targeting CD22
http://library.link/vocab/cover_art
https://contentcafe2.btol.com/ContentCafe/Jacket.aspx?Return=1&Type=S&Value=9783319468778&userID=ebsco-test&password=ebsco-test
Dimensions
unknown
http://library.link/vocab/discovery_link
{'f': 'http://opac.lib.rpi.edu/record=b4258038'}
Extent
XI, 181 p. 57 illus., 39 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319468778
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote

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      42.729766 -73.682577
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