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The Resource Nanoscale Imaging and Characterisation of Amyloid-Beta

Nanoscale Imaging and Characterisation of Amyloid-Beta

Label
Nanoscale Imaging and Characterisation of Amyloid-Beta
Title
Nanoscale Imaging and Characterisation of Amyloid-Beta
Creator
Subject
Language
eng
Member of
Cataloging source
MiAaPQ
Literary form
non fiction
Nature of contents
dictionaries
Series statement
Springer Theses Ser
Nanoscale Imaging and Characterisation of Amyloid-Beta
Label
Nanoscale Imaging and Characterisation of Amyloid-Beta
Link
http://libproxy.rpi.edu/login?url=https://ebookcentral.proquest.com/lib/rpi/detail.action?docID=4584995
Publication
Copyright
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Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • List of Publications -- Academic Publications -- Presentations at Conferences -- Press Articles -- Awards -- Supervisor's Foreword -- Abstract -- Acknowledgments and Dedications -- Acknowledgments -- Dedications -- Contents -- Abbreviations -- 1 Introduction -- Abstract -- References -- 2 Theoretical Concepts of Scanning Probe Microscopy and Dynamic Light Scattering and Their Relation to the Study of Peptide Nanostructures -- Abstract -- 2.1 Introduction -- 2.2 Scanning Probe Microscopy -- 2.2.1 Tip-Surface Interactions -- 2.2.2 AFM Detection Modes -- 2.3 Dynamic Light Scattering (DLS) -- 2.4 Direct Imaging via AFM and Electron Microscopy Studies of AÝ1:42 and Their Findings -- 2.5 Conclusion -- References -- 3 Alzheimer's Disease and the Aggregation of Amyloid Ý -- Abstract -- 3.1 Introduction -- 3.2 Symptoms and Diagnosis -- 3.3 Pathology and Physiology -- 3.4 Epidemiology of AD -- 3.5 Genetic Risk Factors Associated with AD -- 3.6 The Amyloid Precursor Protein -- 3.7 The Amyloid Cascade Hypothesis -- 3.8 Oligomers of AÝ Are Likely to Be the Cause of AD Pathology -- 3.9 Counter Arguments of the Amyloid Cascade Hypothesis -- 3.10 Therapeutic Design for the Treatment of AD -- 3.11 Amyloidosis as the Causative Factor in a Wide Range of Diseases -- 3.12 Conclusions -- References -- 4 Experimental Methodology -- Abstract -- 4.1 Introduction -- 4.2 Materials and General Reagents -- 4.3 Nanomechanical Methods of SPM -- 4.3.1 Nanomechanical Mapping of Peptides and Proteins via Scanning Probe Microscopy -- 4.4 Spectroscopic Methods of SPM -- 4.5 SPM Image Processing and Tip Convolution -- 4.6 Identification of AmyloidÝ by Classical Biomedical Techniques -- 4.6.1 Aggregation Conditions of Amyloid Peptides -- 4.6.2 Monitoring of Aggregation State Using Thioflavin T Assay -- 4.7 Dynamic Light Scattering
  • 4.7.1 Calibration of DLS System Using Gold Nanoparticles -- 4.7.2 Experimental Setup for Temperature Dependent Measurements of LCST Compounds -- 4.7.3 Characterization of Peptide Inhibitor NanoParticle Liposomes Using DLS -- 4.7.4 Detection of AÝ1:40 and 1:42 Using DLS -- 4.8 Substrate Modification for the Attachment of Amyloid Proteins -- 4.8.1 Confirmation of AÝ Attachment to the Substrate -- 4.9 Conclusion -- References -- 5 Substrate Development of the Imaging of Amyloid Proteins with SPM Methods -- Abstract -- 5.1 Introduction -- 5.2 Muscovite Mica as a Standard SPM Substrate -- 5.3 Incubation of AÝ1:42 in Volatile Buffers -- 5.4 Chemical Modification of the Mica Substrate -- 5.4.1 Incubation of Cleaved Mica with Divalent Ions -- 5.4.2 Poly Prep Slides -- 5.4.3 PLL-Mica -- 5.5 Confirmation that PLL Does not Interfere with Fibre Morphology -- 5.6 Confirmation of Attachment of AÝ1:42 to PLL Coated Mica -- 5.7 Conclusion -- References -- 6 Scanning Probe Microscopy Methods of Imaging Amyloid Peptides During the Aggregation Process -- Abstract -- 6.1 Introduction -- 6.2 Tapping Mode Imaging of AÝ1:42-Detection of Metal Ions Induced Alterations in Morphology -- 6.3 UFM of AÝ1:42 -- 6.4 Determination of Fine Structural Details of AÝ1-42 with UFM -- 6.5 Reducing Friction Forces and Sample Damage Artefacts via UFM -- 6.6 Application of UFM Underliquid -- 6.7 Tip Only Ultrasonic Excitation-Waveguide-UFM -- Further Enhancement of the Technique -- 6.8 Conclusion -- References -- 7 Spectroscopy and Thermal SPM Methods of Studying AÝ1:42 -- Abstract -- 7.1 Introduction -- 7.2 Scanning Thermal Microscopy Nanoscale Mapping of Thermal Conductivity of AÝ1:42 -- 7.3 SThM-IR Imaging at Fixed Wavelength of AÝ1:42 -- 7.4 Measurements of AÝ on Anasys "Nano-IR" System -- 7.5 Conclusion -- References
  • 8 The Application of Biophysical Techniques to the Study of the Inhibition of Aggregation of AÝ Using PINPs Liposomes -- Abstract -- 8.1 Introduction -- 8.2 Development of the RI-OR2-TAT PINP Inhibitor -- 8.3 Use of TM-AFM to Confirm the Inhibition of AÝ1:42 Using RI-TAT -- 8.4 Test Study of Non-biological Samples of Well-Defined Behaviours Using DLS -- 8.5 Characterisation of the Morphology and Sizes of PINPs Liposomes -- 8.6 AFM of AÝ1:42 Exposed to RI-OR2-TAT PINPs -- 8.7 Monitoring Aggregation of AÝ1:42 Using DLS -- 8.8 Inhibition of AÝ1:42 Aggregation Using RI-OR2-TAT PINPs as Detected by DLS -- 8.9 Conclusion -- References -- 9 Conclusion and Future Perspectives -- Abstract -- 9.1 Conclusions -- 9.2 Future Perspectives -- References
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{'f': 'http://opac.lib.rpi.edu/record=b4385638'}
Extent
1 online resource (165 pages)
Form of item
online
Isbn
9783319395340
Media category
computer
Media MARC source
rdamedia
Media type code
c
Sound
unknown sound
Specific material designation
remote

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