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The Resource Nanomaterials for Liquid Chromatography and Laser Desorption/Ionization Mass Spectrometry

Nanomaterials for Liquid Chromatography and Laser Desorption/Ionization Mass Spectrometry

Nanomaterials for Liquid Chromatography and Laser Desorption/Ionization Mass Spectrometry
Nanomaterials for Liquid Chromatography and Laser Desorption/Ionization Mass Spectrometry
Tian Lu's dissertation describes major advances in ultrathin-layer chromatography (UTLC), liquid chromatography and surface-assisted laser desorption ionization (SALDI), and matrix-enhanced SALDI (ME-SALDI) mass spectrometry. Lu describes the fabrication of electrospun polyvinyl alcohol (PVA) UTLC plates using an in-situ crosslinking electrospinning technique. The author improved the efficiency of PVA plates greatly compared to the efficiency of silica HPTLC plates. Also highlighted in this thesis is an edge-plane based ordered-carbon surface that provides unique selectivity in liquid chromatography. Further developments include polar analytes, such as amino acids, nucleotides and nucleosides which can be well-retained and separated in the edge-plane ordered-carbon stationary phase. Also, the author studied and detected mass spectra of organic polymers as high as 900,000 Da, the highest molecular weight that has been studied by SALDI to date using the carbon nanofibrous substrate. This thesis has led to a number of publications in high-impact journals
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Nanomaterials for Liquid Chromatography and Laser Desorption/Ionization Mass Spectrometry
Nanomaterials for Liquid Chromatography and Laser Desorption/Ionization Mass Spectrometry
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  • Supervisor's Foreword -- Acknowledgments -- Contents -- Abbreviations -- 1 Introduction -- Abstract -- 1.1{u2026}Concepts and Definitions in Chromatography -- 1.2{u2026}Stationary Phases in Liquid Chromatography -- 1.2.1 Stationary Phases in Normal-Phase Thin Layer Chromatography -- 1.2.2 Carbon Stationary Phases in HPLC -- 1.3{u2026}Sorbents in Solid Phase Extraction -- 1.4{u2026}Substrates for Laser Desorption/Ionization Mass Spectrometry -- References -- 2 Electrospun Polyvinyl Alcohol Ultra-Thin Layer Chromatography of Amino Acids -- Abstract -- 2.1{u2026}Introduction -- 2.2{u2026}Experimental -- 2.2.1 Materials -- 2.2.2 Electrospinning -- 2.2.3 FITC Labeled Amino Acids -- 2.2.4 Thin Layer Chromatography -- 2.2.5 Instrumentation -- 2.3{u2026}Results and Discussion -- 2.3.1 Electrospinning for Optimization of PVA Nanofibrous Mat Structure -- 2.3.2 Selectivity -- 2.3.3 Efficiency -- 2.3.4 Separation of Amino Acids Using Ninhydrin as Visualization Reagent -- 2.3.5 Analysis of Aspartame in Diet Coke -- 2.4{u2026}Conclusions -- References -- 3 Homogeneous Carbon as Stationary Phase for Liquid Chromatography -- Abstract -- 3.1{u2026}Introduction -- 3.2{u2026}Experiment -- 3.2.1 Materials -- 3.2.2 Edge-Plane Carbon Stationary Phase Preparation -- 3.2.3 Characterizations of Carbon Coated Particles -- 3.2.4 Chromatography Studies -- 3.3{u2026}Results and Discussion -- 3.3.1 Synthesis and Characterization of Edge-Plane Carbon Coated Particles -- 3.3.2 Optimization of Carbon Load -- 3.3.3 Van Deemter Plot -- 3.3.4 Linear Solvation Energy Relationship -- 3.3.5 Separation of Nucleosides and Nucleotides -- 3.3.6 Separation of Amino Acids -- 3.3.7 Column to Column Reproducibility -- 3.4{u2026}Conclusion -- References -- 4 Preparation of Homogeneous Basal-Plane Carbon Nanorods and Its Application for Solid Phase Extraction -- Abstract -- 4.1{u2026}Introduction -- 4.2{u2026}Experiments -- 4.2.1 Reagents
  • 4.2.2 Preparation of the Basal-Plane Carbon Nanorods -- 4.2.3 Solid Phase Extraction with the Basal-Plane Carbon Nanorods -- 4.3{u2026}Results and Discussion -- 4.3.1 Preparation and Characterization of the Basal-Plane Carbon Nanorods -- 4.3.2 Solid Phase Extraction -- 4.4{u2026}Conclusion -- References -- 5 Electrospun Nanofibers as Substrates for Surface-Assisted Laser Desorption/Ionization and Matrix-Enhanced Surface-Assisted Laser Desorption/Ionization Mass Spectrometry -- Abstract -- 5.1{u2026}Introduction -- 5.2{u2026}Experimental -- 5.2.1 Materials -- 5.2.2 Electrospinning -- 5.2.3 Fabrication of Carbon Substrates -- 5.2.4 Sample Preparation -- 5.2.5 Instrumentation -- 5.3{u2026}Results and Discussion -- 5.3.1 Fabrication of Electrospun Nanofibrous Substrates -- 5.3.2 SALDI Analysis with Electrospun Nanofibrous Substrates -- Carbon Substrates -- 5.3.3 Polymeric Substrates -- 5.3.4 ME-SALDI Analysis with Electrospun Nanofibrous Substrates -- 5.4{u2026}Conclusion -- References -- 6 Synthesis of Fluorescent Carbon -- Abstract -- 6.1{u2026}Introduction -- 6.2{u2026}Experiment -- 6.2.1 Reagents and Instruments -- 6.2.2 Synthesis of Fluorescent Carbon -- 6.2.3 Measurement of Fluorescence Quantum Yield -- 6.3{u2026}Results and Discussion -- 6.4{u2026}Conclusion -- References -- 7 Future Work -- Abstract -- 7.1{u2026}UTLC Future Work -- 7.2{u2026}Homogeneous Carbon Future Work -- 7.3{u2026}Laser Desorption/Ionization MS Future Work -- References -- VITA
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