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The Resource Molecular targets in protein misfolding and neurodegenerative disease, Pierfausto Seneci

Molecular targets in protein misfolding and neurodegenerative disease, Pierfausto Seneci

Label
Molecular targets in protein misfolding and neurodegenerative disease
Title
Molecular targets in protein misfolding and neurodegenerative disease
Statement of responsibility
Pierfausto Seneci
Creator
Author
Subject
Language
eng
Summary
Aimed at "drug discoverers"--I.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular - the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc
Cataloging source
E7B
Illustrations
illustrations
Index
index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
Molecular targets in protein misfolding and neurodegenerative disease, Pierfausto Seneci
Label
Molecular targets in protein misfolding and neurodegenerative disease, Pierfausto Seneci
Link
http://libproxy.rpi.edu/login?url=http://www.sciencedirect.com/science/book/9780128001868
Publication
Copyright
Related Contributor
Related Location
Related Agents
Related Authorities
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Bibliography note
Includes bibliographical references at the end of each chapters and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • Cover; Title Page; Copyright Page; Dedication; Contents; Abbreviations; Chapter 1 -- Protein Misfolding, Neurodegeneration and Tau; 1.1 -- The neurodegeneration scenario; 1.2 -- Protein folding: physiological benefits and pathological consequences; 1.3 -- Tau: An intrinsically disordered, flexible, and aggregation-prone protein; 1.4 -- Tauopathies: Aggregation-prone tau in neurodegenerative disease (NDD); 1.4.1 -- Class 0 Tauopathies; 1.4.2 -- Class I Tauopathies; 1.4.3 -- Class II Tauopathies; 1.4.4 -- Class III Tauopathies; 1.4.5 -- Class IV Tauopathies; 1.4.6 -- Tau Mutations; References
  • Chapter 2 -- Targeting the Protein Quality Control (PQC) Machinery2.1 -- Molecular chaperones, PQC, and neurodegeneration; 2.2 -- Molecular targets; 2.2.1 -- Hsp27; 2.2.2 -- Hsp70; 2.2.3 -- Hsp90; 2.3 -- Disease-modifying compounds; References; Chapter 3 -- Proteasomal Degradation of Soluble, Misfolded Proteins; 3.1 -- UPS-mediated degradation of misfolded proteins; 3.2 -- UPS-mediated degradation of misfolded proteins in NDDs; 3.3 -- UPS-targets; 3.3.1 -- CHIP; 3.3.2 -- USP14; 3.4 -- Disease-modifying compounds; References; Chapter 4 -- Unselective Disposal of Cellular Aggregates
  • 4.1 -- Autophagy-mediated degradation of protein aggregates4.2 -- Autophagy-mediated degradation of protein aggregates in NDDs; 4.3 -- Macroautophagy-targets; 4.3.1 -- mTORC1; 4.4 -- Disease-modifying compounds; References; Chapter 5 -- Selective Disposal of Insoluble Protein Aggregates; 5.1 -- Aggrephagy-mediated degradation of protein aggregates; 5.2 -- Selective autophagy-mediated degradation of protein aggregates in NDDs; 5.3 -- Selective autophagy-targets; 5.3.1 -- p62; 5.3.2 -- HDAC6; 5.4 -- Disease-modifying compounds; References; Chapter 6 -- Assembly and Disassembly of Protein Aggregates
  • 6.1 -- Introduction6.2 -- Disordered protein aggregates and ordered amyloid fibrils; 6.2.1 -- The Target: Interfering with (Neuro)toxic Tau Species in the Aggregation Process; 6.3 -- Chaperone-driven disaggregation of protein aggregates; 6.3.1 -- The Target: Hsp110; 6.4 -- Disease-modifying compounds; References; Conclusions; Index
http://library.link/vocab/cover_art
https://contentcafe2.btol.com/ContentCafe/Jacket.aspx?Return=1&Type=S&Value=9780128001868&userID=ebsco-test&password=ebsco-test
Dimensions
unknown
http://library.link/vocab/discovery_link
{'f': 'http://opac.lib.rpi.edu/record=b3870532'}
Extent
1 online resource (314 pages)
Form of item
online
Isbn
9780128001868
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations (some color)
Specific material designation
remote
System control number
(OCoLC)893677301

Library Locations

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