Coverart for item
The Resource Molecular pathology of the prions, edited by Harry F. Baker

Molecular pathology of the prions, edited by Harry F. Baker

Label
Molecular pathology of the prions
Title
Molecular pathology of the prions
Statement of responsibility
edited by Harry F. Baker
Contributor
Subject
Language
eng
Summary
It is now widely agreed that the prion protein plays a key role in the molecular pathogenesis of prion diseases-diseases that involve the misfolding of proteins-in both humans and animals. In Molecular Pathology of the Prions, noted prion researcher Harry Baker has asked internationally recognized investigators to review the latest developments in, and novel approaches to, understanding the prion protein and prion diseases at the molecular level. Utilizing a variety of cutting-edge techniques, these distinguished scientists seek to define the normal function of a prion protein, to detect and measure the early immune response to prion disease, and to discover possible therapeutic targets. They also use transgenic mice and new electrophysiological investigations to elucidate the pathogenetic mechanisms involved in prion diseases. Other topics addressed include the neuronal death that occurs in prion disease, the different strains of prion disease agents, and the accumulation of protein deposits within brain parenchyma. State-of-the-art and richly insightful, Molecular Pathology of the Prions captures for basic and clinical neuropathologists the latest developments and approaches to understanding the pathogenesis of prion diseases, including research techniques now likely to enjoy broader application for the more common proteinopathies, such as Alzheimer's and Parkinson's diseases
Member of
Cataloging source
COO
Illustrations
illustrations
Index
index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
Series statement
Methods in molecular medicine
Series volume
59
Molecular pathology of the prions, edited by Harry F. Baker
Label
Molecular pathology of the prions, edited by Harry F. Baker
Link
http://libproxy.rpi.edu/login?url=http://link.springer.com/10.1385/1592591345
Publication
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Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
What would Thomas Henry Huxley have made of prion diseases? / R.M. Ridley -- Prion protein as copper-binding protein at the synapse / H.A. Kretzschmar [and others] -- A function for the prion protein? / D.R. Brown and I.M. Jones -- Prion protein peptide / D.R. Brown -- Characterization of bovine spongiform encephalopathy and scrapie strains/isolates by immunochemical analysis of PRPSC / M.H. Groschup [and others] -- Differential targeting of neurons by prion strains / S.J. DeArmond -- Transgenic studies of prion diseases / G.C. Telling -- Prions: From neurografts to neuroinvasion / M. Glatzel [and others] -- Cellular and transgenic models of familial prion diseases / D.A. Harris [and others] -- Central nervous system inflammation and prion disease pathogenesis / S. Betmouni and V. Hugh Perry -- The electroneuropathology of prion disease / J. Richard Greene -- Transmissible spongiform encephalopathy neurobiology and ultrastructure suggests extracellular PRPSC conversion consistent with classical amyloidosis / M. Jeffrey and J.R. Fraser -- Conformation as therapeutic target in the prionoses and other neurodegenerative conditions / T. Wisniewski [and others] -- Prions of yeast from cytoplasmic genes to heritable amyloidosis / R.B. Wickner [and others]
http://library.link/vocab/cover_art
https://contentcafe2.btol.com/ContentCafe/Jacket.aspx?Return=1&Type=S&Value=9780896039247&userID=ebsco-test&password=ebsco-test
Dimensions
unknown
http://library.link/vocab/discovery_link
{'f': 'http://opac.lib.rpi.edu/record=b3356789'}
Extent
1 online resource (xii, 279 pages)
Form of item
online
Isbn
9780896039247
Lccn
2001026395
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations.
Reproduction note
Electronic reproduction.
Specific material designation
remote
System details
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.

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