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The Resource Micro- And Nano-Scale Assessment of Novel (Trans)Dermal Drug Delivery Strategies : Micro- and Nano-scale Assessments

Micro- And Nano-Scale Assessment of Novel (Trans)Dermal Drug Delivery Strategies : Micro- and Nano-scale Assessments

Label
Micro- And Nano-Scale Assessment of Novel (Trans)Dermal Drug Delivery Strategies : Micro- and Nano-scale Assessments
Title
Micro- And Nano-Scale Assessment of Novel (Trans)Dermal Drug Delivery Strategies
Title remainder
Micro- and Nano-scale Assessments
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Subject
Language
eng
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Cataloging source
MiAaPQ
Literary form
non fiction
Nature of contents
dictionaries
Series statement
Springer Theses Ser
Micro- And Nano-Scale Assessment of Novel (Trans)Dermal Drug Delivery Strategies : Micro- and Nano-scale Assessments
Label
Micro- And Nano-Scale Assessment of Novel (Trans)Dermal Drug Delivery Strategies : Micro- and Nano-scale Assessments
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Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • Parts of this thesis have been published in the following journal articles:H. Garvie-Cook, K. Frederiksen, K. Petersson, R.H. Guy and S.N. Gordeev. Characterisation of topical film-forming systems using atomic force microscopy and Raman micro-spectroscopy. Molecular Pharmaceutics, 12(3):751--757, 2015.H. Garvie-Cook, K. Frederiksen, K. Petersson, R.H. Guy and S.N. Gordeev. Biophysical elucidation of the mechanism of enhanced drug release and topical delivery from polymeric film-forming systems. -- Supervisors' Foreword -- Abstract -- Acknowledgements -- Contents -- Abbreviations and Definitions -- 1 Introduction -- 2 Background -- 2.1 Topical Drug Delivery -- 2.1.1 Structure of the Skin -- 2.1.2 Topical Medication -- 2.1.3 Polymeric Film-Forming Systems -- 2.2 Atomic Force Microscopy -- 2.2.1 Operating Modes for Imaging -- 2.2.2 Nanoindentation -- 2.2.3 AFM Imaging and Nanoindentation in Pharmaceutics -- 2.3 Raman Spectroscopy -- 2.3.1 Raman Chemical Mapping -- 2.3.2 Raman Spectroscopy in Pharmaceutics -- 2.4 Laser Poration -- 2.4.1 SC Penetration Enhancement Methods -- 2.4.2 Laser Ablation -- 2.4.3 Laser Poration of Skin -- References -- 3 Methodology -- 3.1 Film-Forming Systems -- 3.1.1 FFS Preparation -- 3.1.2 Atomic Force Microscopy Imaging -- 3.1.3 AFM Nanoindentation -- 3.1.4 Raman Micro-Spectroscopy -- 3.2 Laser Microporation -- 3.2.1 Preparation of Skin Samples -- 3.2.2 Laser Set-Up -- 3.2.3 Optical Microscopy -- 3.2.4 Raman Micro-Spectroscopy of Porcine Skin -- 3.2.5 Caffeine Delivery -- References -- 4 TEC Plasticization of Topical Polymeric Films -- 4.1 AFM Imaging -- 4.2 AFM Nanoindentation -- 4.2.1 Deformation Behaviour -- 4.2.2 Extraction of Elastic Modulus -- 4.3 Raman Micro-Spectroscopy -- 4.3.1 Constituent Spectra -- 4.3.2 Mapping Concentration -- 4.3.3 Mapping the Physical State of the Drug -- 4.4 Film Formation on Skin
  • 4.5 Summary and Conclusions -- References -- 5 Lipid Incorporation into Topical Polymeric Films -- 5.1 AFM Imaging -- 5.1.1 Interpretation of Tapping Mode Height -- 5.2 AFM Nanoindentation -- 5.2.1 Deformation Behaviour -- 5.2.2 Elastic Moduli -- 5.3 Raman Micro-Spectroscopy -- 5.3.1 MCT Characteristic Spectral Features -- 5.3.2 Mapping Concentration -- 5.3.3 Mapping the Physical State of the Drug -- 5.4 Drug Release Mechanism -- 5.5 Summary and Conclusions -- References -- 6 Laser Microporation of Skin -- 6.1 Pore Dimensions -- 6.1.1 Optical Microscopy of Laser Micropores -- 6.1.2 Variation of Pore Dimensions -- 6.1.3 Beam Propagation -- 6.1.4 Poration Using the Fibre Set-Up -- 6.2 Raman Micro-Spectroscopy -- 6.2.1 Thermal Damage Detection -- 6.2.2 Comparison of Pores in Inked and Uninked Skin -- 6.3 Permeation Enhancement -- 6.4 Mechanism of Ablation -- 6.5 Summary and Conclusions -- References -- 7 Conclusion -- 7.1 Summary of Results -- 7.2 Concluding Remarks
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{'f': 'http://opac.lib.rpi.edu/record=b4384795'}
Extent
1 online resource (127 pages)
Form of item
online
Isbn
9783319289014
Media category
computer
Media MARC source
rdamedia
Media type code
c
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unknown sound
Specific material designation
remote

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