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The Resource Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems, by Marc Thiriet, (electronic resource)

Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems, by Marc Thiriet, (electronic resource)

Label
Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems
Title
Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems
Statement of responsibility
by Marc Thiriet
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Contributor
Author
Subject
Language
eng
Summary
The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors.  Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled.  Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction. Reviews signaling pathways in the regulation of circulatory and respiratory function Describes ion and molecular carriers and receptors Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows
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0
Literary form
non fiction
Series statement
Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems,
Series volume
4
Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems, by Marc Thiriet, (electronic resource)
Label
Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems, by Marc Thiriet, (electronic resource)
Link
http://libproxy.rpi.edu/login?url=http://dx.doi.org/10.1007/978-1-4614-4370-4
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Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
1. Introduction -- 2. Signaling Lipids -- 3. Preamble to Cytoplasmic Protein Kinases -- 4. Cytoplasmic Protein Tyrosine Kinases -- 5. Cytoplasmic Protein Serine/Threonine Kinases -- 6. Dual-Specificity Protein Kinases -- 7. Mitogen-Activated Protein Kinase Module -- 8. Dual-Specificity Protein Kinases -- 9. Guanosine Triphosphatases and Their Regulators -- 10. Other Major Types of Signaling Mediators -- 11. Signaling Pathways -- 12. Conclusion -- References -- List of Currently Used Prefixes and Suffixes -- List of Aliases.-Complementary Lists of Notations -- Index
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{'f': 'http://opac.lib.rpi.edu/record=b3387978'}
Extent
XV, 1064 p. 31 illus.
File format
multiple file formats
Form of item
electronic
Isbn
9781461443704
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote

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