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The Resource Immunotoxin methods and protocols, edited by Walter A. Hall

Immunotoxin methods and protocols, edited by Walter A. Hall

Label
Immunotoxin methods and protocols
Title
Immunotoxin methods and protocols
Statement of responsibility
edited by Walter A. Hall
Contributor
Subject
Language
eng
Summary
More potent and selective for killing cancer cells than chemotherapy, immunotoxins constitute a new class of human therapeutics that have widespread applications and a potential that has not yet been fully recognized. In Immunotoxin Methods and Protocols, leading experts from laboratories around the world describe in step-by-step detail their cutting-edge methods for developing and applying these powerful proteins. The conjugates created by these researchers contain entire monoclonal antibodies, single chain antibody fragments, and cytokines as their carrier ligands. Their toxic portion can include such conventional chemotherapeutics as doxirubicin, such ribosome-inactivating proteins as the ricin A chain or saporin, or such bacterial toxins as diptheria toxin. Also described are a variety of applications that demonstrate the versatility of these agents, including the treatment of primary malignant brain tumors, the generation of selective brain lesions to localize critical functions, and the targeting of the AIDS virus. Each readily reproducible method is optimized for experimental success with hands-on instructions, invaluable notes on pitfalls to avoid, and informative explanations of why certain steps are necessary. Authoritative and highly practical, Immunotoxin Methods and Protocols provides today's cancer researchers, neuroscientists, and oncologists with state-of-the-art tools for exploring these powerful biological agents and their rapidly increasing applications
Member of
Cataloging source
COO
Illustrations
illustrations
Index
index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
Series statement
Methods in molecular biology
Series volume
v. 166
Immunotoxin methods and protocols, edited by Walter A. Hall
Label
Immunotoxin methods and protocols, edited by Walter A. Hall
Link
http://libproxy.rpi.edu/login?url=http://link.springer.com/10.1385/1592591140
Publication
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Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
pt. 1. Immunotoxin construction and development -- Development and activities of the BR96-doxorubicin immunoconjugate -- CD7-specific single chain Fv immunotoxins: design and expresion -- Recombinant fusion toxins directed against the human granulocyte-macrophage colony stimulating factor (GM-CSF) receptor -- Synthesis of monensin derivatives and their effect on the activity of ricin A-chain immuonotoxins -- Purification and conjugation of type 1 ribosome-inactivating proteins -- Comparison of immuotoxins bearing a single saporin molecule with multiple toxin conjugates -- Modulation of growth factor receptor expression by irradiation for immunotoxin targeting -- Quantification of immunotoxin number for complete therapeutic response -- In vitro studies of ricin A-chain-induced vascular leak syndrome -- pt. 2. Oncologic applications of immunotoxins -- Immunotoxin treatment of brain tumors -- Cytotoxins directed at interleukin-4 receptors as therapy for human brain tumors -- Bispecific monoclonal antibiodies for the targeting of type 1 ribosome-inactivating proteins against hematological malignancies -- Tyrosine kinaseinhibitors against EGF receptor-positive malignancies -- Targeting tumor vasculature using VEGF-toxin conjugates -- Gene therapy with immunotoxins -- pt. 3. Alternative applications of immunotoxins -- Effects of selective immunotoxic lesions on learning and memory -- Targeting toxins to neural antigens and receptors -- In vivo testing of anti-HIV immunotoxins
http://library.link/vocab/cover_art
https://contentcafe2.btol.com/ContentCafe/Jacket.aspx?Return=1&Type=S&Value=9781592591145&userID=ebsco-test&password=ebsco-test
Dimensions
unknown
http://library.link/vocab/discovery_link
{'f': 'http://opac.lib.rpi.edu/record=b3356974'}
Extent
1 online resource (xi, 302 pages)
Form of item
online
Isbn
9781592591145
Lccn
00033501
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations.
Specific material designation
remote

Library Locations

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