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The Resource Human Retrotransposons in Health and Disease, edited by Gael Cristofari, (electronic resource)

Human Retrotransposons in Health and Disease, edited by Gael Cristofari, (electronic resource)

Label
Human Retrotransposons in Health and Disease
Title
Human Retrotransposons in Health and Disease
Statement of responsibility
edited by Gael Cristofari
Contributor
Editor
Subject
Language
eng
Summary
This unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80{u2019}s. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-mediated genome variations. These progresses have also led to the discovery that retrotransposon activity is not restricted to the germline - resulting in inheritable genetic variations - but can also mobilize in somatic tissues, such as embryonic stem cells, neuronal progenitor cells, or in many cancers. This book covers topics related to the effects of retrotransposon insertions, and their consequences on germline and somatic genome dynamics, but also discuss the role and impact of retrotransposons sequences in a broader context, including a number of novel topics that emerged recently (long non-coding RNA, neuronal disorders, exaptation) with unexpected connections between retrotransposons, stem cell maintenance, placentation, circadian cycles or aging
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0
Literary form
non fiction
Human Retrotransposons in Health and Disease, edited by Gael Cristofari, (electronic resource)
Label
Human Retrotransposons in Health and Disease, edited by Gael Cristofari, (electronic resource)
Link
http://libproxy.rpi.edu/login?url=http://dx.doi.org/10.1007/978-3-319-48344-3
Publication
Related Contributor
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Related Agents
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Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Retrotransposons and the Mammalian Germline -- L1 regulation in Mouse and Human Germ Cells -- Retrotransposon Contribution to Genomic Plasticity -- The Mobilization of Processed Transcripts in Germline and Somatic Tissues -- Neuronal Genome Plasticity: Retrotransposons, Environment and Disease -- Activity of Retrotransposons in Stem Cells and Differentiated Cells -- Environment, Cellular Signaling and L1 activity -- Retrotransposon-derived Regulatory Regions and Transcripts in Stemness -- Roles of Endogenous Retrovirus-encoded Syncytins in Human Placentation -- Alu-Alu Recombinations in Genetic Diseases -- Retrotransposon-driven Transcription and Cancer -- LINE-1 retrotransposons as Neoplastic Biomarkers -- Contribution of Retrotransposable Elements to Aging
http://library.link/vocab/cover_art
https://contentcafe2.btol.com/ContentCafe/Jacket.aspx?Return=1&Type=S&Value=9783319483443&userID=ebsco-test&password=ebsco-test
Dimensions
unknown
http://library.link/vocab/discovery_link
{'f': 'http://opac.lib.rpi.edu/record=b4258061'}
Extent
X, 330 p. 34 illus., 28 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319483443
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote

Library Locations

    • Folsom LibraryBorrow it
      110 8th St, Troy, NY, 12180, US
      42.729766 -73.682577
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