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The Resource Enzyme kinetics in drug metabolism : fundamentals and applications, edited by Swati Nagar, Upendra A. Argikar, Donald J. Tweedie

Enzyme kinetics in drug metabolism : fundamentals and applications, edited by Swati Nagar, Upendra A. Argikar, Donald J. Tweedie

Label
Enzyme kinetics in drug metabolism : fundamentals and applications
Title
Enzyme kinetics in drug metabolism
Title remainder
fundamentals and applications
Statement of responsibility
edited by Swati Nagar, Upendra A. Argikar, Donald J. Tweedie
Contributor
Editor
Subject
Genre
Language
eng
Summary
Drug metabolism and transport are very important facets within the discipline of pharmaceutical sciences, with?enzyme kinetic concepts utilized regularly in characterizing and modeling the disposition and elimination of drugs. Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications focuses on very practical aspects of applying kinetic principles to drug metabolizing enzymes and transporters. Divided into five convenient sections, topics include the fundamental principles of enzyme kinetics, the kinetics of oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for both drug metabolizing enzymes and transporters including novel systems biology approaches, understanding of variability both experimental and interindividual (pharmacogenomic), and case studies that provide real life examples of applying these principles. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics especially suitable for the novice, in some cases step-by-step, readily reproducible protocols, and insights to help with troubleshooting and avoiding known pitfalls with extensive cross referencing to assist in learning. Authoritative and easily accessible, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications serves as a very practical teaching tool for novice, non-mathematically trained scientists interested in these fundamental concepts and as an aid for their supervisors in teaching these principles
Member of
Cataloging source
GW5XE
Illustrations
illustrations
Index
index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
Series statement
Methods in Molecular Biology,
Series volume
1113
Enzyme kinetics in drug metabolism : fundamentals and applications, edited by Swati Nagar, Upendra A. Argikar, Donald J. Tweedie
Label
Enzyme kinetics in drug metabolism : fundamentals and applications, edited by Swati Nagar, Upendra A. Argikar, Donald J. Tweedie
Link
http://libproxy.rpi.edu/login?url=http://link.springer.com/10.1007/978-1-62703-758-7
Publication
Copyright
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Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase
  • Enzyme Kinetics of Conjugative Enzymes : PAPS
  • Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)
  • Principles and Experimental Considerations for in vitro Transporter Interaction Assays
  • Rationalising Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data : from in vitro Tools to Mechanistic Modeling
  • The Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers
  • Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism
  • Variability in Human in vitro Enzyme Kinetics
  • Sources of Interindividual Variability
  • Case Study 1. Practical Considerations with Experimental Design and Interpretation
  • Enzyme Kinetics in Drug Metabolism : Fundamentals and Applications
  • Case Study 2. Practical Analytical Considerations for Conducting in vitro Enzyme Kinetic Studies
  • Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies : Real Life Examples
  • Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast
  • Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A, MRP2 or OATP1B1 in Drug Development
  • Case Study 6. Drug Transporters: in vitro Solutions for Translatable Outcomes
  • Case Study 7. Compiled Aha Moments in Enzyme Kinetics: Authors' Experiences
  • Fundaments of Enzyme Kinetics
  • Different Enzyme Kinetic Models
  • Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance
  • Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions
  • Multi-Enzyme Kinetics and Sequential Metabolism
  • Consideration of the Unbound Drug Concentration in Enzyme Kinetics
  • Enzyme Kinetics of Oxidative Metabolism : Cytochromes P450
http://library.link/vocab/cover_art
https://contentcafe2.btol.com/ContentCafe/Jacket.aspx?Return=1&Type=S&Value=9781627037570&userID=ebsco-test&password=ebsco-test
Dimensions
unknown
http://library.link/vocab/discovery_link
{'f': 'http://opac.lib.rpi.edu/record=b3540662'}
Extent
1 online resource (xviii, 538 pages)
File format
unknown
Form of item
online
Isbn
9781627037570
Lccn
2013957491
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations (some color).
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote

Library Locations

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