Coverart for item
The Resource Drug targeting : strategies, principles, and applications, edited by G.E. Francis and Cristina Delgado

Drug targeting : strategies, principles, and applications, edited by G.E. Francis and Cristina Delgado

Label
Drug targeting : strategies, principles, and applications
Title
Drug targeting
Title remainder
strategies, principles, and applications
Statement of responsibility
edited by G.E. Francis and Cristina Delgado
Contributor
Subject
Language
eng
Summary
Annotation
Member of
Cataloging source
N$T
Illustrations
illustrations
Index
index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
Series statement
Methods in molecular medicine
Series volume
25
Summary expansion
G.E. Francis and Cristina Delgado have assembled a comprehensive collection of leading-edge protocols for drug targeting studies. In addition to the detailed step-by-step instruction, the protocols review the principal current targeting strategies, discuss how to build the constructs, examine theoretical considerations relevant to solid tumors, and describe experimental and clinical applications of targeted drug delivery systems. Also present are new chemical and biological approaches to the preparation of targeted biopharmaceuticals, including ribonuclease-antibody chimeras, bispecific antibodies, enzyme-antibody conjugates, and folate-bearing conjugates. Applications include the targeting of myocardial infarctions using liposomal systems, the use of monoclonal antibodies to target malaria and HIV-infected cells, the targeting of fusion proteins to leukemias and lymphomas, and the use of antioxidant enzyme-antibody conjugates to target the pulmonary endothelium. Comprehensive and innovative, Drug Targeting: Strategies, Principles, and Applications documents in practical detail the major new chemical and biological targeting methods now being used to produce today's emerging rich array of novel diagnostic agents and promising biopharmaceuticals
Drug targeting : strategies, principles, and applications, edited by G.E. Francis and Cristina Delgado
Label
Drug targeting : strategies, principles, and applications, edited by G.E. Francis and Cristina Delgado
Link
http://libproxy.rpi.edu/login?url=http://link.springer.com/10.1385/1592590756
Publication
Related Contributor
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Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
pt. 1. Strategies -- Chemical construction of immunotoxins -- Construction of ribonuclease-antibody conjugates for selective cytotoxicity -- Intracellular targeting using bispecific antibodies -- Antibody conjugation methods for active targeting of liposomes -- Folate as a targeting device for proteins utilizing folate receptor-mediated endocytosis -- Preparation of recombinant RNase single-chain antibody fusion proteins -- pt. 2. Theoretical aspects -- Practical considerations in the exploitation of passive tumor targeting -- Effect of dose, molecular size, and binding affinity on uptake of antibodies -- Inhibition of tumor blood flow -- pt. 3. Applications -- Targeting in myocardial infarction -- Targeting HIV-infected cells -- Making fusion toxins to targetleukemia and lymphoma -- Antibody-bearing liposomes as chloroquine vehicles in treatment of murine malaria -- Immunotargeting of catalase to the pulmonary vascular endothelium -- Targeted gene transfer: a practical guide based on experience with lipid-based plasmid delivery systems
http://library.link/vocab/cover_art
https://contentcafe2.btol.com/ContentCafe/Jacket.aspx?Return=1&Type=S&Value=9780585395098&userID=ebsco-test&password=ebsco-test
Dimensions
unknown
http://library.link/vocab/discovery_link
{'f': 'http://opac.lib.rpi.edu/record=b3356701'}
Extent
1 online resource (x, 318 pages)
Form of item
online
Isbn
9780585395098
Lccn
99058334
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations.
Specific material designation
remote

Library Locations

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