The Resource Drug targeting : strategies, principles, and applications, edited by G.E. Francis and Cristina Delgado
Drug targeting : strategies, principles, and applications, edited by G.E. Francis and Cristina Delgado
- Summary
- Annotation
- Language
- eng
- Extent
- 1 online resource (x, 318 pages)
- Contents
-
- pt. 1. Strategies
- Chemical construction of immunotoxins
- Construction of ribonuclease-antibody conjugates for selective cytotoxicity
- Intracellular targeting using bispecific antibodies
- Antibody conjugation methods for active targeting of liposomes
- Folate as a targeting device for proteins utilizing folate receptor-mediated endocytosis
- Preparation of recombinant RNase single-chain antibody fusion proteins
- pt. 2. Theoretical aspects
- Practical considerations in the exploitation of passive tumor targeting
- Effect of dose, molecular size, and binding affinity on uptake of antibodies
- Inhibition of tumor blood flow
- pt. 3. Applications
- Targeting in myocardial infarction
- Targeting HIV-infected cells
- Making fusion toxins to targetleukemia and lymphoma
- Antibody-bearing liposomes as chloroquine vehicles in treatment of murine malaria
- Immunotargeting of catalase to the pulmonary vascular endothelium
- Targeted gene transfer: a practical guide based on experience with lipid-based plasmid delivery systems
- Isbn
- 9781592590759
- Label
- Drug targeting : strategies, principles, and applications
- Title
- Drug targeting
- Title remainder
- strategies, principles, and applications
- Statement of responsibility
- edited by G.E. Francis and Cristina Delgado
- Language
- eng
- Summary
- Annotation
- Cataloging source
- N$T
- Illustrations
- illustrations
- Index
- index present
- Literary form
- non fiction
- Nature of contents
-
- dictionaries
- bibliography
- Series statement
- Methods in molecular medicine
- Series volume
- 25
- Summary expansion
- G.E. Francis and Cristina Delgado have assembled a comprehensive collection of leading-edge protocols for drug targeting studies. In addition to the detailed step-by-step instruction, the protocols review the principal current targeting strategies, discuss how to build the constructs, examine theoretical considerations relevant to solid tumors, and describe experimental and clinical applications of targeted drug delivery systems. Also present are new chemical and biological approaches to the preparation of targeted biopharmaceuticals, including ribonuclease-antibody chimeras, bispecific antibodies, enzyme-antibody conjugates, and folate-bearing conjugates. Applications include the targeting of myocardial infarctions using liposomal systems, the use of monoclonal antibodies to target malaria and HIV-infected cells, the targeting of fusion proteins to leukemias and lymphomas, and the use of antioxidant enzyme-antibody conjugates to target the pulmonary endothelium. Comprehensive and innovative, Drug Targeting: Strategies, Principles, and Applications documents in practical detail the major new chemical and biological targeting methods now being used to produce today's emerging rich array of novel diagnostic agents and promising biopharmaceuticals
- Label
- Drug targeting : strategies, principles, and applications, edited by G.E. Francis and Cristina Delgado
- Bibliography note
- Includes bibliographical references and index
- Carrier category
- online resource
- Carrier category code
- cr
- Carrier MARC source
- rdacarrier
- Color
- multicolored
- Content category
- text
- Content type code
- txt
- Content type MARC source
- rdacontent
- Contents
- pt. 1. Strategies -- Chemical construction of immunotoxins -- Construction of ribonuclease-antibody conjugates for selective cytotoxicity -- Intracellular targeting using bispecific antibodies -- Antibody conjugation methods for active targeting of liposomes -- Folate as a targeting device for proteins utilizing folate receptor-mediated endocytosis -- Preparation of recombinant RNase single-chain antibody fusion proteins -- pt. 2. Theoretical aspects -- Practical considerations in the exploitation of passive tumor targeting -- Effect of dose, molecular size, and binding affinity on uptake of antibodies -- Inhibition of tumor blood flow -- pt. 3. Applications -- Targeting in myocardial infarction -- Targeting HIV-infected cells -- Making fusion toxins to targetleukemia and lymphoma -- Antibody-bearing liposomes as chloroquine vehicles in treatment of murine malaria -- Immunotargeting of catalase to the pulmonary vascular endothelium -- Targeted gene transfer: a practical guide based on experience with lipid-based plasmid delivery systems
- http://library.link/vocab/cover_art
- https://contentcafe2.btol.com/ContentCafe/Jacket.aspx?Return=1&Type=S&Value=9781592590759&userID=ebsco-test&password=ebsco-test
- Dimensions
- unknown
- http://library.link/vocab/discovery_link
- {'f': 'http://opac.lib.rpi.edu/record=b3356701'}
- Extent
- 1 online resource (x, 318 pages)
- Form of item
- online
- Isbn
- 9781592590759
- Lccn
- 99058334
- Media category
- computer
- Media MARC source
- rdamedia
- Media type code
- c
- Other physical details
- illustrations.
- Specific material designation
- remote
Embed (Experimental)
Settings
Select options that apply then copy and paste the RDF/HTML data fragment to include in your application
Embed this data in a secure (HTTPS) page:
Layout options:
Include data citation:
<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.lib.rpi.edu/portal/Drug-targeting--strategies-principles-and/FHexxK3iCrs/" typeof="WorkExample http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.lib.rpi.edu/portal/Drug-targeting--strategies-principles-and/FHexxK3iCrs/">Drug targeting : strategies, principles, and applications, edited by G.E. Francis and Cristina Delgado</a></span> - <span property="offers" typeOf="Offer"><span property="offeredBy" typeof="Library ll:Library" resource="http://link.lib.rpi.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.lib.rpi.edu/">Rensselaer Libraries</a></span></span></span></span></div>
Note: Adjust the width and height settings defined in the RDF/HTML code fragment to best match your requirements
Preview
Cite Data - Experimental
Data Citation of the Item Drug targeting : strategies, principles, and applications, edited by G.E. Francis and Cristina Delgado
Copy and paste the following RDF/HTML data fragment to cite this resource
<div class="citation" vocab="http://schema.org/"><i class="fa fa-external-link-square fa-fw"></i> Data from <span resource="http://link.lib.rpi.edu/portal/Drug-targeting--strategies-principles-and/FHexxK3iCrs/" typeof="WorkExample http://bibfra.me/vocab/lite/Item"><span property="name http://bibfra.me/vocab/lite/label"><a href="http://link.lib.rpi.edu/portal/Drug-targeting--strategies-principles-and/FHexxK3iCrs/">Drug targeting : strategies, principles, and applications, edited by G.E. Francis and Cristina Delgado</a></span> - <span property="offers" typeOf="Offer"><span property="offeredBy" typeof="Library ll:Library" resource="http://link.lib.rpi.edu/"><span property="name http://bibfra.me/vocab/lite/label"><a property="url" href="http://link.lib.rpi.edu/">Rensselaer Libraries</a></span></span></span></span></div>
