Coverart for item
The Resource Drug target miRNA : methods and protocols, edited by Marco F. Schmidt

Drug target miRNA : methods and protocols, edited by Marco F. Schmidt

Label
Drug target miRNA : methods and protocols
Title
Drug target miRNA
Title remainder
methods and protocols
Statement of responsibility
edited by Marco F. Schmidt
Contributor
Editor
Subject
Genre
Language
eng
Summary
This volume provides a concise and technical discussion of recently developed approaches to overcome challenges, such as pharmacodynamics and pharmacokinetics difficulties, in miRNA drug discovery. These strategies cover anti-sense agents targeting miRNA that are applied in advanced formulations or are chemically optimized to increase delivery; small molecule miRNA modulators to overcome anti-sense agents' limitations; general enhancers of miRNA maturation; and Argonaute 2 protein and its pharmacokinetic parameters. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Drug Target miRNA: Methods and Protocols is a valuable resource for anyone interested in the ever-evolving field of miRNA drug discovery
Member of
Cataloging source
RML
Illustrations
illustrations
Index
index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
Series statement
Methods in Molecular Biology,
Series volume
1517
Drug target miRNA : methods and protocols, edited by Marco F. Schmidt
Label
Drug target miRNA : methods and protocols, edited by Marco F. Schmidt
Link
http://libproxy.rpi.edu/login?url=http://link.springer.com/10.1007/978-1-4939-6563-2
Publication
Copyright
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Related Location
Related Agents
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Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • Determination of anti-miR association with miRNA/argonaute complexes in vivo
  • Dimitrios G. Zisoulis
  • Competitive argonaute-based RNA immunoprecipitation for investigation of transcriptomic response to anti-miR
  • John R. Androsavich
  • Assessing anti-miR pharmacology with miRNA polysome shift assay
  • John R. Androsavich
  • Evaluating synergistic effects of miR-34a mimics in combination with other therapeutic agents in cultured non-small cell lung cancer cells
  • Jane Zhao and Andreas G. Bader
  • Assessing the off-target effects of miRNA inhibitors on innate immune toll-like receptors
  • Geneviève Pépin, Jonathan Ferrand, and Michael P. Gantier
  • miRNA targeting drugs : the next blockbusters
  • Design of multimodal small molecules targeting miRNAs biogenesis : synthesis and in vitro evaluation
  • Duc D. Vo and Maria Duca
  • Machine learning approaches toward building predictive models for small molecule modulators of miRNA and its utility in virtual screening of molecular databases
  • Vinita Periwal and Vinod Scaria
  • Identification of small molecule modulators of microRNA by library screening
  • Zhangang Xiao and Yangchao Chen
  • Rapid generation of miRNA inhibitor leads by bioinformatics and efficient high-throughput screening methods
  • Christopher L. Haga, Sai Pradeep Velagapudi, Jessica L. Childs-Disney, Jacqueline Strivelli, Matthew D. Disney, and Donald G. Phinney
  • Peptide-based inhibition of miRNA-guided gene silencing
  • Johannes Danner, Balagopal Pai, Ludwig Wankerl, and Gunter Meister
  • Marco F. Schmidt
  • Small molecules targeting the miRNA-binding domain of argonaute 2 : from computer-aided molecular design to RNA immunoprecipitation
  • Teresa Bellissimo, Silvia Masciarelli, Elena Poser, Ilaria Genovese, Alberto Del Rio, Gianni Colotti, and Francesco Fazi
  • Surface plasmon resonance : a useful strategy for the identification of small molecule argonaute 2 protein binders
  • Elena Poser, Ilaria Genovese, Silvia Masciarelli, Teresa Bellissimo, Francesco Fazi, and Gianni Colotti
  • Antagonists of the miRNA-argonaute 2 protein complex : anti-miR-AGOs
  • Marco F. Schmidt, Oliver Korb, and Chris Abell
  • Elucidating mechanisms of molecular recognition between human argonaute and miRNA using computational approaches
  • Hanlun Jiang, Lizhe Zhu, Amélie Héliou, Xin Gao, Julie Bernauer, and Xuhui Huang
  • Kinetic analysis of target RNA binding and slicing by human argonaute 2 protein
  • Sarah Willkomm and Tobias Restle
  • Functional analysis of miRNAs using the DIANA tools online suite
  • Site-specific fluorescent labeling of argonaute for FRET-based bio-assays
  • Sarah Willkomm, Adrian Zander, and Dina Grohmann
  • Single-molecule fluorescence energy transfer assays for the characterization of reaction pathways of miRNA-argonaute complex
  • Myung Hyun Jo and Sungchul Hohng
  • Ioannis S. Vlachos and Artemis G. Hatzigeorgiou
  • Non-nucleotide modification of anti-miRNA oligonucleotides
  • Kim A. Lennox, Christopher A. Vakulskas, and Mark A. Behlke
  • Quantification of oligonucleotide association with miRNA-argonaute complexes in vitro
  • Dimitrios G. Zisoulis
http://library.link/vocab/cover_art
https://contentcafe2.btol.com/ContentCafe/Jacket.aspx?Return=1&Type=S&Value=9781493965632&userID=ebsco-test&password=ebsco-test
Dimensions
unknown
http://library.link/vocab/discovery_link
{'f': 'http://opac.lib.rpi.edu/record=b4160379'}
Extent
1 online resource (xi, 319 pages)
File format
unknown
Form of item
online
Isbn
9781493965632
Lccn
2016956244
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations (some color).
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote

Library Locations

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