Coverart for item
The Resource Diagnostic and therapeutic antibodies, edited by Andrew J.T. George and Catherine E. Urch

Diagnostic and therapeutic antibodies, edited by Andrew J.T. George and Catherine E. Urch

Label
Diagnostic and therapeutic antibodies
Title
Diagnostic and therapeutic antibodies
Statement of responsibility
edited by Andrew J.T. George and Catherine E. Urch
Contributor
Subject
Language
eng
Summary
The use of monoclonal antibodies in treating disease has long held tantalizing promise, and the recent explosion of successful clinical trials-leading to the licensing of novel antibody-based therapeutic agents-has clearly demonstrated the power of recombinant antibody engineering, and greatly rejuvenated interest in their emergent clinical applications. In Diagnostic and Therapeutic Antibodies, a team of experts comprehensively reviews the theoretical and practical aspects of applying antibodies in both the laboratory and clinic. For general understanding, the book thoroughly introduces the basic science of the antibody molecule, including its structure and generation. Several novel in vivo applications of therapeutic antibodies are then presented to illustrate their special value in varied clinical settings. For those new to the field, there are readily reproducible methods for generating and purifying antibodies and for modifying them for clinical application, including how to measure their affinity and immunoactivity, and how to employ them in staining procedures and in a variety of in vitro assays. Timely and comprehensive, Diagnostic and Therapeutic Antibodies offers today{u0260}s clinical researchers a concise introduction to the field, as well as a highly useful compendium of practical protocols that will greatly facilitate the application of these powerful new diagnostic and therapeutic agents
Member of
Cataloging source
YUS
Illustrations
illustrations
Index
index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
Series statement
Methods in molecular medicine
Series volume
40
Diagnostic and therapeutic antibodies, edited by Andrew J.T. George and Catherine E. Urch
Label
Diagnostic and therapeutic antibodies, edited by Andrew J.T. George and Catherine E. Urch
Link
http://libproxy.rpi.edu/login?url=http://link.springer.com/10.1385/1592590764
Publication
Related Contributor
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Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
pt. 1. Introduction -- The antibody molecule / Andrew J.T. George -- Polyclonal and monoclonal antibodies / Mary A. Ritter -- Engineering antibody molecules / Rakesh Verma -- Phage display technology / Michael Johns -- pt. 2. Antibodies in medicine -- Prospects for the application of antibodies in medicine / Herman Waldmann -- Antibodies for neoplastic disease: solid tumors / Ian T.W. Matthews -- The application of monoclonal antibodies in the treatment of lymphoma / Martin J. Glennie -- Antibodies for inflammatory disease: effector cells / Richard Smith -- Antibodies for inflammatory disease: cytokines / Peter C. Taylor -- Antibodies for transplantation / Denise L. Faustman -- Antibody-based therapies in infectious diseases / H. Barbaros Oral -- Antibodies in nuclear medicine / A. Michael Peters -- Animal models for tumor localization / Gail Rowlinson-Busza -- Antibodies for immunoassays / David J. Newman -- pt. 3. Ethics and industry -- Intellectual property / William M. Brown -- From laboratory to clinic: the story of CAMPATH-1 / Geoff Hale -- pt. 4. Production and purification -- Production of monoclonal antibodies / Jóna Freysdóttir -- Purification of monoclonal antibodies using protein A/G / Bridget Heelan -- Preparation of monoclonal antibodies using ion exchange chromatography / Maureen Power -- Quality control of raw materials / Patrick Harrison -- Cell banks and stability of antibody production / Pru Bird -- Measurement of endotoxin / Jenny Phillips -- Aseptic vial filling / Kuldip Bhamra -- Measurement of antibody concentrations by hemagglutination / Jenny Phillips -- pt. 5. Clinical application of antibodies -- Enzymatic digestion of monoclonal antibodies / Sarah M. Andrew -- How to make bispecific antibodies / Ruth R. French -- Radiolabeling of monoclonal antibodies / Calvin S.R. Gooden -- Determination of the immunoreactivity of radiolabeled monoclonal antibodies / Gail Rowlinson-Busza -- Use of biosensors to measure the kinetics of antibody-antigen interactions / Andrew J.T. George -- pt. 6. Application of antibodies in vitro -- How to set up an ELISA / Bill Jordan -- Measurement of HAMA and anti-idiotypic antibodies / Steve Nicholson -- SDS-PAGE and Western blotting / Abdulhamid A. Al-Tubuly -- Flow cytometric analysis / Paul F. McKay -- Immunocytochemistry / Susan Van Noorden -- Immunolabeling for electron microscopy / Catherine E. Sarraf -- pt. 7. Antibody engineering -- PCR of the V region / Rakesh Verma -- Phage display technology: protocols / Michael Johns
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Dimensions
unknown
http://library.link/vocab/discovery_link
{'f': 'http://opac.lib.rpi.edu/record=b3356724'}
Extent
1 online resource (xiv, 477 pages)
File format
unknown
Form of item
online
Isbn
9780585418780
Lccn
99036821
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations.
Quality assurance targets
unknown
Reformatting quality
unknown
Reproduction note
Electronic reproduction.
Sound
unknown sound
Specific material designation
remote
System details
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.

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