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The Resource Decoding the Antibody Repertoire : High Throughput Sequencing of Multiple Transcripts from Single B Cells, by Brandon DeKosky, (electronic resource)

Decoding the Antibody Repertoire : High Throughput Sequencing of Multiple Transcripts from Single B Cells, by Brandon DeKosky, (electronic resource)

Label
Decoding the Antibody Repertoire : High Throughput Sequencing of Multiple Transcripts from Single B Cells
Title
Decoding the Antibody Repertoire
Title remainder
High Throughput Sequencing of Multiple Transcripts from Single B Cells
Statement of responsibility
by Brandon DeKosky
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Author
Subject
Language
eng
Summary
This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening the door for the discovery of new antibodies and the investigation of adaptive immune responses to vaccines and diseases. By designing two new technologies for sequencing multiple mRNA transcripts from up to 10 million isolated, single cells, the author directly addresses the limitations to provide information on the identity of immune receptor pairs encoded by individual B or T lymphocytes. Previous methods for high-throughput immune repertoire sequencing have been unable to provide such information. The techniques developed in this thesis have enabled comprehensive investigation of human B-cell repertoires and have been applied for the rapid discovery of new human antibodies, to gain new insights into the development of human antibody repertoires, and for analysis of human immune responses to vaccination and disease
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0
Literary form
non fiction
Series statement
Springer Theses, Recognizing Outstanding Ph.D. Research,
Decoding the Antibody Repertoire : High Throughput Sequencing of Multiple Transcripts from Single B Cells, by Brandon DeKosky, (electronic resource)
Label
Decoding the Antibody Repertoire : High Throughput Sequencing of Multiple Transcripts from Single B Cells, by Brandon DeKosky, (electronic resource)
Link
http://libproxy.rpi.edu/login?url=http://dx.doi.org/10.1007/978-3-319-58518-5
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Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Background -- High-throughput Sequencing of the Paired Human Immunoglobulin Heavy and Light Chain Repertoire -- In-Depth Determination and Analysis of the Human Paired Heavy and Light Chain Antibody Repertoire -- Paired VH:VL Analysis of Naïve B Cell Repertoires and Comparison to Antigen-Experienced B Cell Repertoires in Healthy Human Donors -- Conclusions and Future Perspectives -- Appendices
http://library.link/vocab/cover_art
https://contentcafe2.btol.com/ContentCafe/Jacket.aspx?Return=1&Type=S&Value=9783319585185&userID=ebsco-test&password=ebsco-test
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unknown
http://library.link/vocab/discovery_link
{'f': 'http://opac.lib.rpi.edu/record=b4258224'}
Extent
XXVIII, 87 p. 34 illus.
File format
multiple file formats
Form of item
electronic
Isbn
9783319585185
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote

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