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The Resource Cyclin dependent kinase (CDK) inhibitors : methods and protocols, edited by Mar Orzaez, Monica Sancho Medina, Enrique Perez-Paya

Cyclin dependent kinase (CDK) inhibitors : methods and protocols, edited by Mar Orzaez, Monica Sancho Medina, Enrique Perez-Paya

Label
Cyclin dependent kinase (CDK) inhibitors : methods and protocols
Title
Cyclin dependent kinase (CDK) inhibitors
Title remainder
methods and protocols
Statement of responsibility
edited by Mar Orzaez, Monica Sancho Medina, Enrique Perez-Paya
Contributor
Editor
Subject
Language
eng
Summary
This volume contains a collection of relevant information for drug discovery in cell cycle research. Protocols to develop screening assays or to identify novel CDK inhibitors are discussed in the first part of the book. The second part of the book describes elaborate procedures to evaluate activity and mechanism of action of new and already identified CDK inhibitors. The third part of the book talks about protocols to evaluate metabolomics changes associated to inhibitor treatment. Drug delivery strategies focused on nanoparticle development to provide alternative internalization systems for increasing inhibitor efficacy are also described. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Cyclin-Dependent Kinase (CDK) Inhibitors: Methods and Protocols is a useful tool for scientists interested in this research field
Member of
Cataloging source
RML
Illustrations
illustrations
Index
index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
Series statement
Methods in molecular biology,
Series volume
volume 1336
Cyclin dependent kinase (CDK) inhibitors : methods and protocols, edited by Mar Orzaez, Monica Sancho Medina, Enrique Perez-Paya
Label
Cyclin dependent kinase (CDK) inhibitors : methods and protocols, edited by Mar Orzaez, Monica Sancho Medina, Enrique Perez-Paya
Link
http://libproxy.rpi.edu/login?url=http://link.springer.com/10.1007/978-1-4939-2926-9
Publication
Copyright
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Antecedent source
file reproduced from original
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
mixed
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • Fragment-based de novo design of cyclin-dependent kinase 2 inhibitors
  • Sunil Kumar Tripathi, Poonam Singh, and Sanjeev Kumar Singh
  • Protein-protein interaction for the de novo design of cyclin-dependent kinase peptide inhibitors
  • Karthiga Arumugasamy, Sunil Kumar Tripathi, Poonam Singh, and Sanjeev Kumar Singh
  • Identification of cyclin a binders with a fluorescent peptide sensor
  • Elena Pazos, José L. Mascareñas, and M. Eugenio Vázquez
  • Cell synchronization techniques to study the action of CDK inhibitors
  • Beatriz Pérez-Benavente and Rosa Farràs
  • Analysis of CDK inhibitor action on mitochondria-mediated apoptosis
  • Anna Gortat
  • Immunoprecipitation of cdk-cyclin complexes for determination of kinase activity
  • Evaluating the effects of CDK inhibitors in ischemia-reperfusion injury models
  • Tatiana Guevara
  • Assessing cell cycle independent function of the CDK inhibitor p21CDKN1A in DNA repair
  • Ilaria Dutto, Micol Tillhon, and Ennio Prosperi
  • Drug delivery strategies of chemical CDK inhibitors
  • Daniel Alvira and Laura Mondragón
  • Animal models for studying the in vivo functions of cell cycle CDKs
  • Sanjiv Risal, Deepak Adhikari, and Kui Liu
  • Evaluating chemical CDK inhibitors as cell death inducers
  • Hiroshi Hirai and Yoko Nakatsuru
  • Edurne Gallastegui and Oriol Bachs
  • Models for the study of the cross talk between inflammation and cell cycle
  • Laura J. Hoodless, Calum T. Robb, Jennifer M. Felton, Carl S. Tucker, and Adriano G. Rossi
  • Metabolomic applications to the characterization of the mode-of-action of CDK inhibitors
  • Martina Palomino-Schätzlein and Antonio Pineda-Lucena
  • Expression and purification of recombinant cyclins and CDKs for activity evaluation
  • Edurne Gallastegui and Oriol Bachs
  • Expression and purification of recombinant CDKs : CDK7, CDK8, and CDK9
  • Reena Pinhero and Krassimir Yankulov
  • Preparation of CDK/cyclin inhibitor complexes for structural determination
  • Asterios I. Grigoroudis and George Kontopidis
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Dimensions
unknown
http://library.link/vocab/discovery_link
{'f': 'http://opac.lib.rpi.edu/record=b3681899'}
Extent
1 online resource (x, 227 pages)
File format
unknown
Form of item
online
Isbn
9781493929269
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations (some color).
Quality assurance targets
unknown
Reformatting quality
access
Sound
unknown sound
Specific material designation
remote

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