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The Resource Chromatin Architecture : Advances From High-resolution Single Molecule DNA Imaging, by Kirti Prakash, (electronic resource)

Chromatin Architecture : Advances From High-resolution Single Molecule DNA Imaging, by Kirti Prakash, (electronic resource)

Label
Chromatin Architecture : Advances From High-resolution Single Molecule DNA Imaging
Title
Chromatin Architecture
Title remainder
Advances From High-resolution Single Molecule DNA Imaging
Statement of responsibility
by Kirti Prakash
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Author
Subject
Language
eng
Summary
This book sheds new light on the current state of knowledge concerning chromatin organization. Particular emphasis is given to the new imaging potential offered by super-resolution microscopy, which allows DNA imaging with a very high labeling density. From the early work on chromosomes by Walther Flemming in the nineteenth century to recent advances in genomics, the history of chromatin research now spans more than a century. The various milestones, such as the discovery of the double helix structure, the sequencing of the human genome, and the recent description of the genome in 3D space, show that understanding chromatin and chromosome function requires a clear understanding of its structure. Presenting cutting-edge data from super-resolution single molecule microscopy, the book demonstrates that chromatin manifests several levels of folding, from nucleosomes to chromosomes. Chromatin domains emerge as a new fundamental building block of chromatin architecture, with functions possibly related to gene regulation. A detailed description of chromatin folding in the pachytene stage of meiosis serves as a model for exploring this functionality, showing the apparent interplay between structure, function, and epigenetic regulation. Lastly, the book discusses possible new avenues of innovation to describe chromatin{u2019}s organization and functions. Gathering essential insights on chromatin architecture, the book offers students an introduction to microscopy and its application to chromatin organization, while also providing advanced readers with new ideas for future research
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0
Literary form
non fiction
Series statement
Springer Theses, Recognizing Outstanding Ph.D. Research,
Chromatin Architecture : Advances From High-resolution Single Molecule DNA Imaging, by Kirti Prakash, (electronic resource)
Label
Chromatin Architecture : Advances From High-resolution Single Molecule DNA Imaging, by Kirti Prakash, (electronic resource)
Link
http://libproxy.rpi.edu/login?url=http://dx.doi.org/10.1007/978-3-319-52183-1
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Antecedent source
mixed
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
not applicable
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
A Condensed History of Chromatin Research -- Investigating Chromatin Organisation Using Single Molecule Localisation Microscopy -- Structure, Function and Dynamics of Chromatin -- Periodic and Symmetric Organisation of Meiotic Chromosomes -- Conclusions -- Appendices
http://library.link/vocab/cover_art
https://contentcafe2.btol.com/ContentCafe/Jacket.aspx?Return=1&Type=S&Value=9783319521831&userID=ebsco-test&password=ebsco-test
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unknown
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{'f': 'http://opac.lib.rpi.edu/record=b4258122'}
Extent
LIII, 152 p. 101 illus., 50 illus. in color.
File format
multiple file formats
Form of item
electronic
Isbn
9783319521831
Level of compression
uncompressed
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
online resource.
Quality assurance targets
absent
Reformatting quality
access
Specific material designation
remote

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