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The Resource Chemosensitivity, Volume 1, In vitro assays, edited by Rosalyn D. Blumenthal

Chemosensitivity, Volume 1, In vitro assays, edited by Rosalyn D. Blumenthal

Label
Chemosensitivity, Volume 1, In vitro assays
Title
Chemosensitivity
Title number
Volume 1
Title part
In vitro assays
Statement of responsibility
edited by Rosalyn D. Blumenthal
Title variation
In vitro assays
Contributor
Subject
Genre
Language
eng
Summary
Chemosensitivity testing is an ex vivo means of determining or enhancing the cytotoxic and/or cytostatic, or apoptosis-inducing effects of anticancer drugs. In Chemosensitivity, leading researchers and physicians working in academia and biotech companies describe state-of-the-art laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Volume 1: In Vitro Assays provides a panel of 16 in vitro measures of chemosensitivity in adherent and nonadherent cells for single agents and combinations of agents. In addition to immunohistochemical and imaging approaches, these assays include clonogenic, colorimetric, fluorometric, and physiological assays. Highlights include image analysis to assess drug sensitivity, high throughput approaches using green fluorescent protein, DIMSCAN (a microcomputer fluorescence-based assay), and the ChemoFx assay used in biotechnology. The protocols follow the successful Methods in Molecular Medicine series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. The authors also provide guidance on how best to analyze the data derived from the protocols. A companion volume, Volume 2: In Vivo Models, Imaging, and Molecular Regulators, provides protocols for classifying tumors into response categories and customizing chemotherapy regimens to individual patients. Cutting-edge and highly practical, the two volumes of Chemosensitivity provide a comprehensive collection of readily reproducible techniques for the in vitro and in vivo screening of new agents and a set of proven approaches to understand mechanistically why certain cancer cell lines (in vitro) of tumors (in vivo) are more, or less, sensitive to a particular agent
Member of
Cataloging source
N$T
Illustrations
illustrations
Index
index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
Series statement
Methods in molecular medicine
Series volume
110
Chemosensitivity, Volume 1, In vitro assays, edited by Rosalyn D. Blumenthal
Label
Chemosensitivity, Volume 1, In vitro assays, edited by Rosalyn D. Blumenthal
Link
http://libproxy.rpi.edu/login?url=http://link.springer.com/10.1385/1592598692
Publication
Related Contributor
Related Location
Related Agents
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Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
v. 1. An overview of chemosensitivity testing / R.D. Blumenthal -- Clonogenic cell survival assay / A. Munshi [and others] -- High-sensitivity cytotoxicity assays for nonadherent cells / M. Jules Mattes -- Sulforhodamine B assay and chemosensitivity / W. Voigt -- Use of the differential staining cytotoxicity assay to predict chemosensitivity / G.J. Kaspers -- Collagen gel droplet culture method to examine in vitro chemosensitivity / H. Kobayashi -- The MTT assay to evaluate chemosensitivity / J.D. Burton -- Histoculture drug response assay to monitor chemoresponse / S. Ohie [and others] -- In vitro testing of chemosensitivity in physiological hypoxia / R. Grigoryan [and others] -- Chemosensitivity testing using microplate adenosine triphosphate-based luminescence measurements / C.M. Kurbacher and I.A. Cree -- High-throughput technology: Green fluorescent protein to monitor cell death / M. Fortin [and others] -- DIMSCAN : A microcomputer fluorescence-based cytotoxicity assay for preclinical testing of combination chemotherapy / N. Keshelava [and others] -- The ChemoFx assay: An ex vivo cell culture assay for predicting anticancer drug responses / R.L. Ochs [and others] -- Evaluating response to antineoplastic drug combinations in tissue culture models / C.P. Reynolds and B.J. Maurer -- Image analysis using the fluorochromasia assay to quantify tumor drug sensitivity / J.F. Gibbs [and others] -- Immunohistochemical detection of ornithine decarboxylase as a measure of chemosensitivity testing / U. Bachrach -- Immunohistochemistry of p53, Bcl-2, and Ki-67 as predictors of chemosensitivity / M. Itaya [and others]
http://library.link/vocab/cover_art
https://contentcafe2.btol.com/ContentCafe/Jacket.aspx?Return=1&Type=S&Value=9781592598694&userID=ebsco-test&password=ebsco-test
Dimensions
unknown
http://library.link/vocab/discovery_link
{'f': 'http://opac.lib.rpi.edu/record=b3356897'}
Extent
1 online resource (1 volume)
File format
unknown
Form of item
online
Isbn
9781592598694
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations.
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote

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