Coverart for item
The Resource Chemical proteomics : methods and protocols, edited by Gerard Drewes and Marcus Bantscheff

Chemical proteomics : methods and protocols, edited by Gerard Drewes and Marcus Bantscheff

Label
Chemical proteomics : methods and protocols
Title
Chemical proteomics
Title remainder
methods and protocols
Statement of responsibility
edited by Gerard Drewes and Marcus Bantscheff
Contributor
Subject
Genre
Language
eng
Summary
The multidisciplinary science of chemical proteomics studies how small molecules of synthetic or natural origin bind to proteins and modulate their function. In Chemical Proteomics: Methods and Protocols, expert researchers in the field provide key techniques to investigate chemical proteomics focusing on analytical strategies, how probes are generated, techniques for the discovery of small molecule targets and the probing of target function, and small molecule ligand and drug discovery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Chemical Proteomics : Methods and Protocols seeks to provide methodologies that will contribute to a wider application of chemical proteomics methods in biochemical and cell biological laboratories
Member of
Cataloging source
GW5XE
Index
index present
Literary form
non fiction
Nature of contents
dictionaries
Series statement
Methods in molecular biology,
Series volume
803
Chemical proteomics : methods and protocols, edited by Gerard Drewes and Marcus Bantscheff
Label
Chemical proteomics : methods and protocols, edited by Gerard Drewes and Marcus Bantscheff
Link
http://libproxy.rpi.edu/login?url=http://link.springer.com/10.1007/978-1-61779-364-6
Publication
Note
Includes index
Related Contributor
Related Location
Related Agents
Related Authorities
Related Subjects
Related Items
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Mass spectrometry-based chemoproteomic approaches -- Chemical proteomics in drug discovery -- Compound immobilization and drug-affinity chromatography -- Affinity-based chemoproteomics with small molecule-peptide conjugates -- A chemical proteomic probe for detecting dehydrogenases: Catechol rhodanine -- Probing proteomes with benzophenone photoprobes -- Biotinylated probes for the analysis of protein modification by electrophiles -- Profiling of methyltransferases and other S-adenosyl-l: -homocysteine-binding proteins by capture compound mass spectrometry -- Identifying cellular targets of small-molecule probes and drugs with biochemical enrichment and SILAC -- Determination of kinase inhibitor potencies in cell extracts by competition binding assays and isobaric mass tags -- Affinity-based profiling of dehydrogenase subproteomes -- Probing the specificity of protein-protein interactions by quantitative chemical proteomics -- Fluorescence-based proteasome activity profiling -- Chemical cross-linking and high-resolution mass spectrometry to study protein-drug interactions -- Monitoring ligand modulation of protein-protein interactions by chemical cross-linking and high-mass MALDI mass spectrometry -- Time-controlled transcardiac perfusion crosslinking for in vivo interactome studies -- Ligand discovery using small-molecule microarrays -- Working with small molecules: Preparing and storing stock solutions and determination of kinetic solubility -- A database for chemical proteomics: ChEBI -- Working with small molecules: Rules-of-thumb of "Drug likeness."
http://library.link/vocab/cover_art
https://contentcafe2.btol.com/ContentCafe/Jacket.aspx?Return=1&Type=S&Value=9781617793646&userID=ebsco-test&password=ebsco-test
Dimensions
unknown
http://library.link/vocab/discovery_link
{'f': 'http://opac.lib.rpi.edu/record=b3357703'}
Extent
1 online resource (xi, 313 pages).
File format
unknown
Form of item
online
Isbn
9781617793646
Lccn
2011937567
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote

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