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The Resource Chemical genomics : reviews and protocols, edited by Edward D. Zanders

Chemical genomics : reviews and protocols, edited by Edward D. Zanders

Label
Chemical genomics : reviews and protocols
Title
Chemical genomics
Title remainder
reviews and protocols
Statement of responsibility
edited by Edward D. Zanders
Contributor
Subject
Genre
Language
eng
Summary
Chemical genomics is an exciting new field that promises to transform biological chemistry into a high-throughput industrialized process, much in the same way that genomics has transformed molecular biology. In Chemical Genomics: Reviews and Protocols, leading edge researchers introduce the uninitiated into the various "flavors" of chemical genomics and describe a series of readily reproducible techniques for applications in organic chemistry, protein chemistry, and computer science, with emphasis on the high-throughput approaches that are the essence of chemical genomics. The techniques range from the classic design of small molecules as affinity ligands for specific protein families, to in silico docking for computational approaches, to protein-small molecule interactions, to producing highly diverse collections of proteins, carbohydrates, and small molecules for use in arrays containing large numbers of these molecules. There are also methods for the production of proteins and carbohydrates using different expression systems, for analyzing proteins using mass spectrometry, and for arraying proteins and carbohydrates on solid supports. The protocols follow the successful Methods in Molecular Biology series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Authoritative and timely, Chemical Genomics: Reviews and Protocols offers researchers an accessible introduction by pioneers to the key areas and methods of chemical genomics, as well as its use in the discovery and evaluation of novel drug targets
Member of
Cataloging source
COO
Illustrations
illustrations
Index
index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
Series statement
Methods in molecular biology
Series volume
v. 310
Chemical genomics : reviews and protocols, edited by Edward D. Zanders
Label
Chemical genomics : reviews and protocols, edited by Edward D. Zanders
Link
http://libproxy.rpi.edu/login?url=http://link.springer.com/10.1007/978-1-59259-948-6
Publication
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Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • Introduction to chemical genomics / Paul R. Caron -- Chemistry for chemical genomics / Lutz Weber -- Computer-aided design of small molecules for chemical genomics / Philip M. Dean -- Design, synthesis, and screening of biomimetic ligands for affinity chromatography / Ana Cecília A. Roque, Geeta Gupta, and Christopher R. Lowe -- The role and application of in silico docking in chemical genomics research / Aldo Jongejan [and others] -- Synthesis of complex carbohydrates and glyconjugates: enzymatic synthesis of globotetraose using 1,3-N-acetylgalactosaminyltransferase LgtD from Haemophilus infuenzae strain Rd / Kang Ryu [and others] -- High-throughput cloning for proteomics research / Sharon A. Doyle
  • Screening for the expression of soluble recombinant protein in Escherichia coli / Sharon A. Doyle -- High-throughput purification of hexahistidine-tagged proteins expressed in Escherichia coli / Michael B. Murphy and Sharon A. Doyle -- The wheat germ cell-free expression system: methods for high-throughput materialization of genetic information / Tatsuya Sawasaki [and others] -- Advances in genome-wide protein expression using the wheat germ cell-free system / Yaeta Endo and Tatsuya Sawasaki -- Production of proteins for NMR studies using the wheat germ cell-free system / Toshiyuki Kohno -- Adenoviral expression of reporter proteins for high-throughput cell-based screening / Jon Hoyt and Randall W. King
http://library.link/vocab/cover_art
https://contentcafe2.btol.com/ContentCafe/Jacket.aspx?Return=1&Type=S&Value=9781588293992&userID=ebsco-test&password=ebsco-test
Dimensions
unknown
http://library.link/vocab/discovery_link
{'f': 'http://opac.lib.rpi.edu/record=b3357113'}
Extent
1 online resource (xi, 279 pages)
Form of item
online
Isbn
9781588293992
Lccn
2005013118
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations.
Specific material designation
remote

Library Locations

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