Coverart for item
The Resource Alzheimer's disease : methods and protocols, edited by Nigel M. Hooper

Alzheimer's disease : methods and protocols, edited by Nigel M. Hooper

Label
Alzheimer's disease : methods and protocols
Title
Alzheimer's disease
Title remainder
methods and protocols
Statement of responsibility
edited by Nigel M. Hooper
Contributor
Subject
Genre
Language
eng
Summary
With the molecular mechanisms underlying the various forms of muscular dystrophy now rapidly clarifying, precise diagnosis has become a reality, and even a requirement in clinical practice. In Muscular Dystrophy: Methods and Protocols, Katherine Bushby and Louise Anderson have assembled an outstanding collection of key techniques for the analysis of DNA and protein from patients suspected to suffer from muscular dystrophy. Each method is highly detailed to ensure success and is presented by a hands-on expert who uses it on a day-to-day basis. The various DNA techniques focus on both the X-linked muscular dystrophies and the autosomal recessive muscular dystrophies. The protein methods include expression analysis, multiplex western blot analysis, immunocytochemical analysis, and reviews of immunological reagants and of amplification systems. Also discussed are the use of animal models to understand human muscular dystrophy and the available options for gene-based therapy. Comprehensive and highly practical, Muscular Dystrophy: Methods and Protocols offers today{u0260}s diagnostic laboratories, basic and medical researchers, and active clinicians an authoritative collection of tools that will serve as exacting diagnostic tools as well as greatly empowering research on the novel therapeutics now beginning to emerge
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Member of
Cataloging source
YUS
Illustrations
illustrations
Index
index present
Language note
English
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • handbooks
Series statement
Methods in molecular medicine
Series volume
32
Alzheimer's disease : methods and protocols, edited by Nigel M. Hooper
Label
Alzheimer's disease : methods and protocols, edited by Nigel M. Hooper
Link
http://libproxy.rpi.edu/login?url=http://link.springer.com/10.1385/1592591957
Publication
Note
Source of title; title from Title page
Related Contributor
Related Location
Related Agents
Related Authorities
Related Subjects
Related Items
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Introduction to Alzheimer's disease / D. Allsop-The genetics of Alzheimer's disease / N. Brindle and P.S. George-Hyslop-Advances in methodology and current prospects for primary drug therapies for Alzheimer's disease / D.S. Knopman-Production and functional assays of recombinant secreted amyloid precursor protein (app) (sappalpha) / S.W. Barger-Quantifying abeta(1-40) and abeta (1-42) using sandwich-elisa / D.M. Skovronsky [and others]-Electrophoretic separation and immunoblotting of abeta(1-40) and abeta (1-42) / M. Staufenbiel and P.A. Paganetti-Abeta-induced proinflammatory cytokine release from differentiated human thp-1 monocytes / K.R. Brunden [and others]-Effects of the beta-amyloid peptide on membrane ion permeability / H.A. Pearson-Analysis of beta-amyloid peptide degradation in vitro / B. Cordell and A. Naidu-Posttranslational modifications of amyloid precursor protein : Ectodomain phosphorylation and sulfation / J. Walter and C. Haass-Posttranslational modifications of the amyloid precursor protein : Glycosylation / C. Liu [and others]-Using an amyloid precursor protein (app) reporter to characterize alpha-secretase / S.B. Roberts-Inhibition of alpha-secretase by zinc metalloproteinase inhibitors / S. Parvathy, A.J. Turner and N.M. Hooper-Development of neoepitope antibodies against the beta-secretase cleavage site in the amyloid precursor protein / C.W. Gray and E.H. Karran-Beta-secretase : Tissue culture studies of sequence specificity, inhibitors, and candidate enzymes / M. Citron-Using beta-secretase inhibitors to distiguish the generation of the abeta peptides terminating at val-40 and ala-42 / P.A. Paganetti and M. Staufenbiel-Designing animal models of Alzheimer's disease with amyloid precursor protein (app) transgenes / J.F. Loring-Phosphorylation of amyloid precursor protein (app) family proteins / T. Suzuki [and others]-Determining the transmembrane topology of the presenilins / G. Thinakaran and A. Doan-Normal proteolytic processing of the presenilins / H. Hartmann and B.A. Yankner-Apoptotic proteolytic cleavage of the presenilins by caspases / T.W. Kim-The phosphorylation of presenilin proteins / J. Walter-Interaction of the presenilins with the amyloid precursor protein (APP) / A. Weidemann [and others]-Distribution of presenilins and amyloid precursor protein (APP) in detergent-insoluble membrane domains / E.T. Parkin, A.J. Turner and N.M. Hooper-Characterization and use of monoclonal antibodies to tau and paired helical filament tau / P. Davies-Tau phosphorylation both in vitro and in cells / C.H. Reynolds, G.M. Gibb and S. Lovestone-Transglutaminase-catalyzed formation of Alzheimer-like insoluble complexes from recombinant tau / B.J. Balin and D.M. Appelt
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Dimensions
unknown
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{'f': 'http://opac.lib.rpi.edu/record=b3356700'}
Extent
1 online resource (xiv, 408 pages)
File format
unknown
Form of item
online
Isbn
9780585395074
Issuing body
Digitization of Biomedprotocols made available on the world wide web by Humana Press.
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations.
Quality assurance targets
unknown
Reformatting quality
unknown
Reproduction note
Electronic reproduction.
Sound
unknown sound
Specific material designation
remote
System details
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.

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